NFKBIB
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Official Full Name
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta -
Overview
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene. -
Synonyms
NFKBIB;IKBB;TRIP9;nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta;NF-kappa-B inhibitor beta;ikB-B;TRIP-9;ikB-beta;ikappaBbeta;NF-kappa-BIB;I-kappa-B-beta;TR-interacting protein 9;thyroid receptor-interacting protein 9
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Zebrafish
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- E. coli
- His
- His&MBP
- His&T7
- Non
- GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
NFKBIB involved in several pathways and played different roles in them. We selected most pathways NFKBIB participated on our site, such as Chemokine signaling pathway,NOD-like receptor signaling pathway,RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFKBIB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Epstein-Barr virus infection | CD40,PLCG2,HLA-DRA,POLR3G,TBP,POLR1C,POLR3E,TBK1,MAPK11,TYK2 |
| Shigellosis | NFKB1,U2AF1L4,PFN2,CTTN,NFKBIA,RAC1,WASF1,PFN3,ELMO3,BTRC |
| NOD-like receptor signaling pathway | IKBKG,TNFAIP3,NFKBIAA,RELA,CASPA,SUGT1,TRIP6,CXCL2,RIPK2,PSTPIP1A |
| Cytosolic DNA-sensing pathway | TREX1,POLR3F,OSTN,POLR2L,IFNA21,POLR2E,IFNA2,POLR2H,IFNA8,IFNA14 |
| T cell receptor signaling pathway | CD28,NFATC1,PIK3R3,PIK3CG,OXSR1A,NFKB1,NCK2,PPP3R1,ICOS,PAK7 |
| B Cell Receptor Signaling Pathway | NRAS,ARPC5,AKT2,BLK,SOS1,PTPN18,HRAS,PIK3CB,DOK3,PDPK1A |
| Chemokine signaling pathway | CCL25,CX3CL1,STAT1,IL-8,PXN,CCL2,CCL21B,GRB2,CXCL11,CXCR3 |
| Adipocytokine signaling pathway | IKBKG,IRS4,ACSL3A,NFKBIE,NPY,CPT1C,STK11,POMC,AKT3A,PRKAG3B |
| RIG-I-like receptor signaling pathway | IFNA13,TP-1,MAPK14A,MAPK12,MAPK10,IFNB,IL-8,DHX58,Ifna11,IFNA4 |
Protein Function
NFKBIB has several biochemical functions, for example, protein binding,signal transducer activity,transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NFKBIB itself. We selected most functions NFKBIB had, and list some proteins which have the same functions with NFKBIB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| signal transducer activity | FAM126A,OLFCJ1,PLCL2,FPR3,RHOC,PLCXD2,OLFR492,PLEKHB1,TAS2R136,FPR-RS6 |
| protein binding | RNF32,SF1,CYB561,NAPRT1,INTS7,EVI5L,SQSTM1,MRPS9,ZNF165,GJA1 |
| transcription coactivator activity | TAF11,MAML2,NCOA2,HIF3A,YAF2,TDRD3,LPIN1,GATA3,MTF1,RARA |
Interacting Protein
NFKBIB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFKBIB here. Most of them are supplied by our site. Hope this information will be useful for your research of NFKBIB.
RELA;FBXW11;VPS52;p14340-pro_0000037965;polg_den2n;MCC;MYO9A;NFKB2
NFKBIB Related Signal Pathway
Resources
Research Area
Transcription Regulators in Endothelial CellsIkB Proteins
Inflammatory Mediators
Intracellular Factors in Inflammation
Intracellular Kinases in the Akt Pathway
IkB Kinase (IKK)
Natural Killer T (NKT) Cells
C-type Lectin Receptors
NOD-like Receptors and the Inflammasome
RIG-I-like Receptors
IL-1 Family Signaling Molecules
IL-17 Signaling Related Molecules
Related Services
Related Products
References
- Esposito, S; Ierardi, V; et al. Genetic polymorphisms and risk of recurrent wheezing in pediatric age. BMC PULMONARY MEDICINE 14:-(2014).
- Wing, MR; Devaney, JM; et al. DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC Study. NEPHROLOGY DIALYSIS TRANSPLANTATION 29:864-872(2014).
