NDUFB6
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Official Full Name
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -
Overview
The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. -
Synonyms
NDUFB6;NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa;NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6 (17kD, B17);NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6;B17;CI;complex I;mitochondrial respiratory chain;B17 subunit;NADH ubiquinone oxidoreductase B17 subunit;NADH ubiquinone oxidoreductase beta subunit;6;CI B17;CI-B17;Complex I mitochondrial respiratory chain B17 subunit;Complex I-B17;Complex IB17;MGC13675;MS108;NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 6;NADH ubiquinone oxidoreductase beta subunit 6;NADH-ubiquinone oxidoreductase B17 subunit;NDUB6_HUMAN;OTTHUMP00000021179;OTTHUMP00000021180;NADH-ubiquinone oxidoreductase beta subunit, 6;complex I, mitochondrial respiratory chain, B1
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Chicken
- Mouse
- Pongo Abelii
- Pongo Pygmaeus
- Gorilla gorilla gorilla (Western lowland gorilla)
- Sus scrofa (Pig)
- Mus musculus
- Pan troglodytes
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
NDUFB6 involved in several pathways and played different roles in them. We selected most pathways NDUFB6 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFB6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-alcoholic fatty liver disease (NAFLD) | NDUFS7,NDUFS6,COX7A1,NDUFC1,PIK3CD,PRKAG1,NDUFA2,NDUFS2,PIK3CB,CASP8 |
| Parkinsons disease | PARK2,NDUFAB1,CASP9,UQCRC2,SLC25A31,NDUFA12,NDUFS2,UCHL1,SLC18A1,COX8C |
| Oxidative phosphorylation | UQCRC1,ATP6V0CB,NDUFS8B,COX5B2,ATP5J,ATP6V0D1,NDUFS8,ATP6AP2,NDUFS5,NDUFA4 |
| Huntingtons disease | DNAH6,UQCRB,DNAH14,TFAM,COX5A,NDUFA10,TBPL2,DNAIC2,SOD1,IFT57 |
| Metabolic pathways | ALAS2,GBA3,AMY1A,CYP3A7,B3GNT2,BTD,UPB1,MSMO1,ALOX15,ACOT8 |
| Alzheimers disease | COX6C,NDUFA12,BID,APH1B,COX6B2,PLCB2,NDUFA9,NDUFC1,COX7A2,NDUFA6 |
Protein Function
NDUFB6 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFB6 itself. We selected most functions NDUFB6 had, and list some proteins which have the same functions with NDUFB6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADH dehydrogenase (ubiquinone) activity | NDUFV2,NDUFA9,NDUFA8,NDUFB9,NDUFS6,NDUFA2,NDUFA5,NDUFS1,NDUFC2-KCTD14,NDUFC2 |
Interacting Protein
NDUFB6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFB6 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFB6.
TMBIM4;NDUFS5;NDUFS3;NDUFA6;NDUFA11;Kif19;TIMMDC1;NDUFA12;NDUFAF1
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References
- Szendrodi, J; Rose, B; et al. Update on the molecular fundamentals of nutrition. DIABETOLOGE 5:432-+(2009).
