NCOA3
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- Overview
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Official Full Name
nuclear receptor coactivator 3 -
Overview
There are three members of the steroid receptor co-activator (SRC) family of proteins: SRC-1 (NCoA-1), SRC-2 (TIF2/GRIP1/NCoA-2), and SRC-3 (ACTR/pCIP/RAC3/TRAM-1/AIB1). All SRC family members share significant structural homology and function to stimulat -
Synonyms
NCOA3;nuclear receptor coactivator 3;ACTR;AIB1;bHLHe42;CAGH16;KAT13B;p/CIP;RAC3;receptor associated coactivator 3;SRC 3;SRC3;thyroid hormone receptor activator molecule 1;TNRC16;TRAM 1;CBP-interacting protein;receptor-associated coactivato
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NCOA3-7035H | Recombinant Human RAC3, His-tagged | E.coli | Human | His | Full length | |
| NCOA3-121H | Recombinant Human NCOA3, GST-tagged | Wheat Germ | Human | GST |
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| Ncoa3-1350R | Recombinant Rat Ncoa3 protein, His & T7-tagged | E.coli | Rat | His&T7 | Met1~Arg269 |
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| NCOA3-3941HCL | Recombinant Human NCOA3 293 Cell Lysate | HEK293 | Human | Non |
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| NCOA3-5199H | Recombinant Human NCOA3 Protein (Gly1023-Ala1304), N-His tagged | E.coli | Human | His | Gly1023-Ala1304 |
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Involved Pathway
NCOA3 involved in several pathways and played different roles in them. We selected most pathways NCOA3 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCOA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone signaling pathway | TBC1D4,NOTCH3,RXRB,SRC,HDAC2,PFKFB2,HIF1A,PIK3CD,PLCD1,PRKCA |
Protein Function
NCOA3 has several biochemical functions, for example, androgen receptor binding,chromatin binding,histone acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NCOA3 itself. We selected most functions NCOA3 had, and list some proteins which have the same functions with NCOA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | ARID3A,ENY2,DNAJC2,NCOA2,ERG,BRD3,TOX2,IFT74,POU5F3,CITED1 |
| transcription factor activity, RNA polymerase II transcription factor recruiting | LIF |
| histone acetyltransferase activity | CLOCK,CSRP2BP,METTL8,TAF1,KAT7,KAT7B,NCOA1,MED24,MGEA5,CDYL |
| protein dimerization activity | HER8.2,DBI,TFEC,PPP3CA,HIF1AL2,MXD1,PEF1,CELSR1,ID2A,NLGN1 |
| protein binding | CC10,CD8A,UIMC1,NR3C2,RARS,AMHR2,MOBKL2B,HES1,POLL,SMG5 |
| ligand-dependent nuclear receptor transcription coactivator activity | SMARCD3,AASS,PRKCB,SS18,CCAR1,CALCOCO1,MED4,CARM1,HMGA1-RS1,TADA3 |
| ligand-dependent nuclear receptor binding | ARID1A,C1D,TRIP4,JUND,MED1,SMARCE1,PPARGC1A,NCOR1,NR1H4,UBA3 |
| androgen receptor binding | NCOA1,PIAS2,CCNE1,CTNNB1,DAXX,KDM4C,EP300,RB1,TCF21,DDX5 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | SRF,ELF1,JUN,CRX,CTCFL,SPI1,FOXC2,POU2F3,ONECUT1,RBPJ |
Interacting Protein
NCOA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCOA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCOA3.
SPOP;PSME3;EP300;PSMB9;ESR1;RARA
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References
- Harada, K; Kakuda, Y; et al. Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis. JOURNAL OF CLINICAL PATHOLOGY 67:396-402(2014).
- Mirza, S; Rakha, EA; et al. Cytoplasmic localization of alteration/deficiency in activation 3 (ADA3) predicts poor clinical outcome in breast cancer patients. BREAST CANCER RESEARCH AND TREATMENT 137:721-731(2013).
