NCF2
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Official Full Name
neutrophil cytosolic factor 2 -
Overview
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010] -
Synonyms
NCF2;neutrophil cytosolic factor 2;NCF-2;NOXA2;P67PHOX;P67-PHOX;neutrophil cytosol factor 2;NADPH oxidase activator 2;67 kDa neutrophil oxidase factor;neutrophil NADPH oxidase factor 2;chronic granulomatous disease, autosomal 2;neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2)
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- Mammalian Cells
- Wheat Germ
- Insect Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi&Fc&His
- GST&His
- DDK&Myc
- Flag
Involved Pathway
NCF2 involved in several pathways and played different roles in them. We selected most pathways NCF2 participated on our site, such as Phagosome,Osteoclast differentiation,Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Leukocyte transendothelial migration | ITGA4,RAC2,ARHGAP5,EZR,MYL7,CLDN1,CLDN15,CXCR4,CLDN14,BCAR1 |
| Osteoclast differentiation | IL1A,RAC1,FOSL1,FCGR1,SQSTM1,PIK3CA,FOS,FCGR2B,MAPK12,NOX1 |
| Leishmaniasis | HLA-DRB5,PTGS2,HLA-DQA1,PRKCB,IRAK4,HLA-DRB1,ITGA4,IFNGR1,TGFB2,NCF4 |
| Phagosome | ATP6V0E1,BF2,HLA-DMA,ATP6V0C,TUBA2,RILP,RAB7A,CTSSB.1,SEC22BA,M6PR |
Protein Function
NCF2 has several biochemical functions, for example, Rac GTPase binding,electron carrier activity,protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCF2 itself. We selected most functions NCF2 had, and list some proteins which have the same functions with NCF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rac GTPase binding | ARFIP2,SOD1,PAK6,SRGAP3,EPS8,PAK3,RAB7A,RALBP1,HACE1,NOXA1 |
| protein C-terminus binding | AP2A1,PRDX3,PROP1,CEP135,ERBB2,MED12,VGLL3,HPCAL4,FIGN,SDCBP |
| electron carrier activity | GRXCR1,SDHD,SDHC,XDH,FDX1,GCDHB,AOX4,NDUFA12,ACADS,SRD5A1 |
| protein binding | LRRC4,PLD1,CTDNEP1,RFX1,CORO6,PADI4,COX5A,WRN,EIF4EBP2,COL1A1 |
Interacting Protein
NCF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCF2.
NCF1;NCF4;CDC42
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References
- Davis, NA; Lareau, CA; et al. Encore: Genetic Association Interaction Network Centrality Pipeline and Application to SLE Exome Data. GENETIC EPIDEMIOLOGY 37:614-621(2013).
- Savchenko, VL; et al. Regulation of NADPH Oxidase Gene Expression with PKA and Cytokine IL-4 in Neurons and Microglia. NEUROTOXICITY RESEARCH 23:201-213(2013).
