NAV1
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Official Full Name
neuron navigator 1 -
Overview
This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009] -
Synonyms
NAV1;neuron navigator 1;POMFIL3;UNC53H1;STEERIN1;unc-53 homolog 1;neuron navigator-1;pore membrane and/or filament interacting like protein 3;pore membrane and/or filament-interacting-like protein 3
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NAV1-1198H | Recombinant Human NAV1, His-tagged | E.coli | Human | His | 1359-1530aa | |
| NAV1-3690H | Recombinant Human NAV1 protein, GST-tagged | E.coli | Human | GST | 1359-1530 aa | |
| NAV1-10443M | Recombinant Mouse NAV1 Protein | Mammalian Cells | Mouse | His |
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| NAV1-1028H | Recombinant Human NAV1 protein, His-tagged | E.coli | Human | His | 1362-1492aa |
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| NAV1-1029H | Recombinant Human NAV1 protein, His-tagged | E.coli | Human | His | 1098-1756aa |
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| NAV1-5923M | Recombinant Mouse NAV1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NAV1-5923M-B | Recombinant Mouse NAV1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
NAV1 involved in several pathways and played different roles in them. We selected most pathways NAV1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NAV1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
NAV1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NAV1 itself. We selected most functions NAV1 had, and list some proteins which have the same functions with NAV1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SMAD3,TGFA,CCBL1,FTH1,GCM1,SH2B1,AIG1,FNTA,RPL27A,RBMY1B |
Interacting Protein
NAV1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NAV1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NAV1.
TBC1D4;APC;MAPK1;YWHAB
Resources
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References
- Hien, YE; Montersino, A; et al. CK2 accumulation at the axon initial segment depends on sodium channel Nav1. FEBS LETTERS 588:3403-3408(2014).
- Xia, L; Dou, NN; et al. Upregulation of Nav1.8 in Demyelinated Facial Nerves Might be Relevant to the Generation of Hemifacial Spasm. JOURNAL OF CRANIOFACIAL SURGERY 25:1334-1336(2014).
