NAT8L
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Official Full Name
N-acetyltransferase 8-like (GCN5-related, putative) -
Overview
This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia). -
Synonyms
NAT8L;N-acetyltransferase 8-like (GCN5-related, putative);N acetyltransferase 8 like;N-acetylaspartate synthetase;FLJ37478;Hcml3;CML3;N acetyltransferase 8 like (GCN5 related, putative);NAT8 like;NAA synthetase;camello-like protein 3;NACED;NAT8-LIKE
Recombinant Proteins
- Mouse
- Rat
- Human
- Zebrafish
- zebrafish
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Mus musculus
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
NAT8L involved in several pathways and played different roles in them. We selected most pathways NAT8L participated on our site, such as Alanine, aspartate and glutamate metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NAT8L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ENO1,AKR1C4,HPSE,ACADM,B4GALNT1,CYP26C1,MOGAT3,HSD3B4,APRT,PIGU |
| Alanine, aspartate and glutamate metabolism | GAD2,GLUD2,ASL2,ALDH5A1,ASNS,GOT2B,GAD1,GLULB,FOLH1,ADSSL1 |
Protein Function
NAT8L has several biochemical functions, for example, aspartate N-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NAT8L itself. We selected most functions NAT8L had, and list some proteins which have the same functions with NAT8L. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
NAT8L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NAT8L here. Most of them are supplied by our site. Hope this information will be useful for your research of NAT8L.
Resources
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References
- Uno, K; Miyamoto, Y; et al. SHATI/NAT8L REGULATES DOPAMINE RELEASE-INDUCED BY NICOTINE IN NUCLEUS ACCUMBENS. ALCOHOL AND ALCOHOLISM 49:-(2014).
- Nitta, A; Iegaki, N; et al. N-Acetyltransferase Shati/Nat8l in the Dorsal Striatum Regulates Sociability and Motivation via Control of the Serotonergic Neuronal System in Mice. NEUROPSYCHOPHARMACOLOGY 39:S534-S535(2014).
