NASP

  • Official Full Name

    nuclear autoantigenic sperm protein (histone-binding)

  • Overview

    This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa.

  • Synonyms

    NASP;nuclear autoantigenic sperm protein (histone-binding);nuclear autoantigenic sperm protein;DKFZp547F162;FLB7527;FLJ31599;FLJ35510;MGC2297;MGC19722;MGC20372;PRO1999;5033430J04Rik;AI131596;AI317140;D4Ertd767e;Epcs32;MGC93869;NASP_HUMAN;nuclear autoantigenic sperm protein (histone binding);RP23 233B9.9;histone H1-binding protein

Recombinant Proteins

  • Zebrafish
  • Rat
  • Human
  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • His&T7
  • Non
  • Myc&DDK
  • His&Fc&Avi
  • Flag

    Involved Pathway

    NASP involved in several pathways and played different roles in them. We selected most pathways NASP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NASP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    NASP has several biochemical functions, for example, Hsp90 protein binding,histone binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NASP itself. We selected most functions NASP had, and list some proteins which have the same functions with NASP. You can find most of the proteins on our site.

    Function Related Protein
    protein complex binding ATP6V0D1,ADM2,GNB2,ATM,LCA5,KRIT1,DISC1,C8B,PPARA,ATF1
    histone binding ATAD2,CTSL2,CTCFL,HIST1H4I,ZMYND11,USP49,HINFP,RAG1,CD1d1,MCM2
    protein binding OSTC,CX3CR1,HIST3H3,MSRB3,FCN2,KISS1,ATP6V1E1,PRMT6,HIST1H2AH,MT1F
    Hsp90 protein binding PPID,STUB1,CSNK2A1,PPEF2,FKBP6,CHORDC1,AHR,CDC37,HDAC6,PACRG

    Interacting Protein

    NASP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NASP here. Most of them are supplied by our site. Hope this information will be useful for your research of NASP.

    HIST1H3D;TERF2IP;SGK1;BCAR3;TFE3;MCC;HLA-B;GABARAPL2;ARF6;IKBKE;FTSJ1;TRAF6;PTK2;TERF2;HIST2H3D;yvmA;ULK2;HDAC6

    Resources

    References

    • Ali-Fehmi, R; Chatterjee, M; et al. Analysis of the expression of human tumor antigens in ovarian cancer tissues. CANCER BIOMARKERS 6:33-48(2010).
    • Wang, M; Shi, JL; et al. The antibody against a nuclear autoantigenic sperm protein can result in reproductive failure. ASIAN JOURNAL OF ANDROLOGY 11:183-192(2009).

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