NAGA
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Official Full Name
N-acetylgalactosaminidase, alpha- -
Overview
NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. Mutations in NAGA have been identified as the cause ofSchindler disease types I and II (type II also known as Kanzaki disease). -
Synonyms
NAGA;N-acetylgalactosaminidase, alpha-;alpha-N-acetylgalactosaminidase;D22S674;Alpha galactosidase B;Acetylgalactosaminidase, alpha N (alpha galactosidase B);Alpha N acetylgalactosaminidase;GALB;N acetylgalactosaminidase, alpha;alpha-galactosidase B;Acetylgalactosaminidase, alpha-N- (alpha-galactosidase B)
Recombinant Proteins
- Human
- Mouse
- Rat
- C.perfringens
- Zebrafish
- Chicken
- Bacillus subtilis
- E.coli
- Human Cells
- Mammalian Cells
- HEK293
- E.Coli/Yeast
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
NAGA involved in several pathways and played different roles in them. We selected most pathways NAGA participated on our site, such as Glycosphingolipid biosynthesis - globo series,Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with NAGA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosphingolipid biosynthesis - globo series | GBGT1,GLA,ST3GAL2,HEXB,FUT9,GBGT1L4,B3GALT5,B3GALNT1,A4GALT,HEXA |
| Lysosome | TPP1,M6PR,CTSG,ATP6V0CA,GALCB,GLB1,CTSW,CLTCB,MFSD8,ACP2 |
Protein Function
NAGA has several biochemical functions, for example, alpha-N-acetylgalactosaminidase activity,alpha-galactosidase activity,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NAGA itself. We selected most functions NAGA had, and list some proteins which have the same functions with NAGA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alpha-galactosidase activity | GLA |
| protein homodimerization activity | GOLGA5,SYT10,GPD1A,USH1G,AMBP,GNPTG,BNIP3,RAB11FIP4B,SERPINF2,GLA |
Interacting Protein
NAGA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NAGA here. Most of them are supplied by our site. Hope this information will be useful for your research of NAGA.
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References
- Qing, YF; Zhang, QB; et al. Changes in toll-like receptor (TLR)4-NF kappa B-IL1 beta signaling in male gout patients might be involved in the pathogenesis of primary gouty arthritis. RHEUMATOLOGY INTERNATIONAL 34:213-220(2014).
- Choi, CW; An, HY; et al. Characterization of Streptococcus pneumoniae N-Acetylglucosamine-6-Phosphate Deacetylase as a Novel Diagnostic Marker. JOURNAL OF MICROBIOLOGY 51:659-664(2013).
