MYO9B
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Official Full Name
myosin IXB -
Overview
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
MYO9B;myosin IXB;CELIAC4;myosin-IXb;CELIAC 4;Celiac disease 4;MYO 9B;Myosin 9B;Myosin IX;Myosin9B;MyosinIX;MyosinIXB;MYR 5;MYR5;Unconventional myosin 9b;unconventional myosin-9b;unconventional myosin IXb
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MYO9B-1146H | Recombinant Human MYO9B, GST-tagged | E.coli | Human | GST | 1660-1983aa | |
| MYO9B-2790H | Recombinant Human MYO9B protein, His-tagged | E.coli | Human | His | 1660-1983 aa | |
| MYO9B-5474C | Recombinant Chicken MYO9B | Mammalian Cells | Chicken | His |
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| MYO9B-5848H | Recombinant Human MYO9B Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
MYO9B involved in several pathways and played different roles in them. We selected most pathways MYO9B participated on our site, such as Fcgamma receptor (FCGR) dependent phagocytosis,Immune System,Innate Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYO9B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fcgamma receptor (FCGR) dependent phagocytosis | WASF2,BAIAP2,ACTR2,PLD4,NCKIPSD,WASF3,MYO1C,IgG3,ACTR2B,PPAPDC1A |
| Regulation of RhoA activity | MCF2L,DEF6,ARAP1,OBSCN,ARHGEF10,AKAP13,FARP1,ARHGEF25,ARHGEF18,ARHGEF10L |
| Immune System | ADAR,ERAP1,OSCAR,SH2D1B,UBE2F,IFI27,HECTD3,TRIM68,UBE2J2,FBXO44 |
| Regulation of actin dynamics for phagocytic cup formation | ABI1B,MYO1C,WIPF2,WIPF3,ABI1A,NCKIPSD |
| Rho GTPase cycle | ARHGEF18,RHOF,DCLRE1B,ARHGAP1,ARHGAP28,GMIP,ARHGAP12B,OPHN1,ARHGAP10,STARD8 |
| Innate Immune System | LRRFIP1,WIPF2,WIPF3,MGC174152,KIR2DS2,BAIAP2,CRCP,PELI1,SUGT1,POLR3H |
| Signal Transduction | PROKR1A,BCO2L,PDK2B,ARHGEF18,TNKS,STAM2,LRP10,ARHGAP4A,RSPO3,DNAL4 |
| Signaling by Rho GTPases | TAGAPA,RHOT1A,ABI1A,ARHGAP12,ARHGAP17B,ARHGAP25,ARHGAP31,KIF14,RHOV,ROPN1 |
Protein Function
MYO9B has several biochemical functions, for example, ADP binding,ATP binding,ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MYO9B itself. We selected most functions MYO9B had, and list some proteins which have the same functions with MYO9B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | RASAL1,ADAP1,RGS3,ARHGEF19,HTR2B,ARHGAP23,TBC1D10B,ARHGAP26,DEPDC1B,GNAQ |
| NOT protein homodimerization activity | MLXIPL,DDIT3,MSH3,KCNA3,MECOM,EXT2,MSH6,NUDT16L1 |
| calmodulin binding | CDK5RAP2,NDUFAF4,ITPKC,NOS1,IQGAP3,MARCKS,CAMK1D,MYH1B,MKNK1,DAPK2 |
| microfilament motor activity | MYH3,MYO7A,MYO3B,MYH7,STRC,MYH9,MYO1E,MYH8,MYO3A,MYO5A |
| ATPase activity | MYO19,HLTF,CHD1L,PSMC4,ABCC1,ABCE1,ABCA5,NSFA,VCP,ABCF2 |
| protein binding | FOXP3,TCP1,PLEKHB2,RCAN3,DDX20,SLC9A3,C19orf57,LIMS1,SIN3B,NEDD4 |
| ADP binding | P2RY1,MYO3A,CHORDC1,MYO7A,MYO18A,GCLC,ME1,PRPS2,TAP1,MYH9 |
| ATP binding | MCM6L,PHKG1A,MLKL,HSP90B1,DHX58,NSFA,ADCK1,C9orf96,TUT1,ATAD3A |
| metal ion binding | NEK8,TRIM35-21,RSAD2,CLEC7A,MARCH5L,KDM7AB,CSGALNACT1,EGLN1B,DROSHA,ZEB1B |
Interacting Protein
MYO9B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYO9B here. Most of them are supplied by our site. Hope this information will be useful for your research of MYO9B.
LRRC41;PKN2;tuf;MOB4;MYC
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References
- Wolters, VM; Alizadeh, BZ; et al. Intestinal barrier gene variants may not explain the increased levels of antigliadin antibodies, suggesting other mechanisms than altered permeability. HUMAN IMMUNOLOGY 71:392-396(2010).
- Casella, G; D'Inca, R; et al. Prevalence of celiac disease in inflammatory bowel diseases: An IG-IBD multicentre study. DIGESTIVE AND LIVER DISEASE 42:175-178(2010).
