MYO5A
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Official Full Name
myosin VA (heavy chain 12, myoxin) -
Overview
This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of;actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA;translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene;cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or;Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported,;but the full-length nature of some variants has not been determined. -
Synonyms
MYO5A;myosin VA (heavy chain 12, myoxin);MYH12, myosin VA (heavy polypeptide 12, myoxin);unconventional myosin-Va;GS1;MYO5;myosin heavy chain 12;myosin V;myosin;heavy polypeptide kinase;myoxin;MYR12;myosin-12;myosin-Va;myosin, heavy polypep
Recombinant Proteins
- Mouse
- Rat
- Chicken
- Human
- Mammalian Cells
- E.coli
- HEK293
- Wheat Germ
- His
- His&T7
- His&Fc&Avi
- GST
Involved Pathway
MYO5A involved in several pathways and played different roles in them. We selected most pathways MYO5A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MYO5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MYO5A has several biochemical functions, for example, ATP binding,ATP-dependent protein binding,Rab GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYO5A itself. We selected most functions MYO5A had, and list some proteins which have the same functions with MYO5A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | MARCKSB,ATPIF1,SPHK1,EEF2K,ADD1,AEBP1,MKNK2A,MIP,IQCB1,SPA17 |
| microfilament motor activity | MYH7,MYO3A,MYH8,MYH9,MYO1E,MYH13,MYO3B,MYO9B,MYH3,STRC |
| motor activity | MYH4,DYNLT3,MYO6,DNALC4,MYH15,DYNC1I1,MYH1E,KIF5A,DNAL4,MYO1A |
| syntaxin-1 binding | CCDC167,LRRK2,GOLSYN,SNAP25A,STXBP2,RNF40,STXBP3A,VAMP2,VAMP3,NSF |
| protein heterodimerization activity | TGFB1,HEYL,CRLF1,HIST1H4B,DDIT3,DVL3,SMAD4,ADD2,CA,ZHX1 |
| actin binding | TMOD3,CLMN,KCNMA1,WASH1,ESPN,TWF1B,ANLN,PTK2,PARVB,INF2 |
| poly(A) RNA binding | NUCKS1,HIST1H4D,MRPS15,RPL7,PURG,GLRX3,DUSP14,ZCCHC24,BCCIP,RPL10 |
| nucleotide binding | NT5C3L,UCK2A,Aatk,RAC1A,HSP70L,PSMC1B,Atp8a2,ZCRB1,SR140,TRIOA |
| calcium ion binding | NCALD,CAPN1A,MGMT,CALML5,MAN1A,PCDH18A,LPCAT2,PCDH15A,TLL1,LCP1 |
Interacting Protein
MYO5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYO5A here. Most of them are supplied by our site. Hope this information will be useful for your research of MYO5A.
Grin1;Grin2b;Slc17a9;Nos1;NPHP4;Csf1;SNCA;Hmga2;Ywhae;Ywhab
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