MYL5
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Official Full Name
myosin, light chain 5, regulatory -
Overview
This gene encodes one of the myosin light chains, a component of the hexameric ATPase cellular motor protein myosin. Myosin is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene product, one of the regulatory light chains, is expressed in fetal muscle and in adult retina, cerebellum, and basal ganglia. -
Synonyms
MYL5;myosin, light chain 5, regulatory;myosin, light polypeptide 5, regulatory;myosin light chain 5;MYL 5;MYL5_HUMAN;MyLC 2;MyLC-2;MYLC2;Myosin light chain 5 regulatory;Myosin light polypeptide 5;Myosin light polypeptide 5 regulatory;Myosin regulatory light chain 5;Superfast myosin regulatory light chain 2;OTTHUMP00000217187;OTTHUMP00000217188;OTTHUMP00000217190;OTTHUMP00000217193
Recombinant Proteins
- Human
- E.coli
- Human
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MYL5-29364TH | Recombinant Human MYL5, His-tagged | E.coli | Human | His | 173 amino acids |
|
| MYL5-3622H | Recombinant Human MYL5, His-tagged | Human | Human | His |
|
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| MYL5-6875H | Recombinant Human Myosin, Light Chain 5, Regulatory, His-tagged | E.coli | Human | His | 1-173aa |
|
| MYL5-4025HCL | Recombinant Human MYL5 293 Cell Lysate | HEK293 | Human | Non |
|
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| MYL5-2489H | Recombinant Human MYL5 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| MYL5-301610H | Recombinant Human MYL5 protein, GST-tagged | E.coli | Human | GST | 233-313 a.a. |
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| MYL5-5812H | Recombinant Human MYL5 Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| MYL5-6762HF | Recombinant Full Length Human MYL5 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 132 amino acids |
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Involved Pathway
MYL5 involved in several pathways and played different roles in them. We selected most pathways MYL5 participated on our site, such as Focal adhesion,Tight junction,Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Actin Cytoskeleton | FGF10A,VCLA,NCKAP1L,PAK6,GNA13A,ARHGEF6,ITGB2L,ITGA5,PIP5K1B,MYH10 |
| Focal adhesion | PIK3R3A,SOS1,ITGB1A,BIRC2,VTNB,GRB2B,HRASB,COL2A1B,ITGB7,SRC |
| Leukocyte transendothelial migration | PIK3R2,CLDN9,MAPK13,ITGAM,ESAM,ITGB1,CYBA,CDC42,ARHGAP5,RAC2 |
| Tight junction | CLDNC,MYH15,MYL7,CASKA,CASK,RHOAC,ACTN2,EPB41L2,PARD3,ACTB2 |
Protein Function
MYL5 has several biochemical functions, for example, calcium ion binding,structural constituent of muscle. Some of the functions are cooperated with other proteins, some of the functions could acted by MYL5 itself. We selected most functions MYL5 had, and list some proteins which have the same functions with MYL5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | NINL,S100A14,RHOT1B,VIL1,CHP2,ALOX8,CBLB,S100A10B,DGKAA,MEX3B |
| structural constituent of muscle | MYL1,MYL2,MYOM1,CAPN3,MYL9,TTN,NEXN,MYBPH,TPM1,ANKRD2 |
Interacting Protein
MYL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYL5.
Resources
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References
- Kakei, T; Sumiyoshi, H; et al. Characteristics of light chains of Chara myosin revealed by immunological investigation. PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES 88:201-211(2012).
- Vicente-Manzanares, M; Horwitz, AR; et al. Myosin light chain mono- and di-phosphorylation differentially regulate adhesion and polarity in migrating cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 402:537-542(2010).
