MXD4
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Official Full Name
MAX dimerization protein 4 -
Overview
This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. -
Synonyms
MXD4;MAX dimerization protein 4;bHLHc12;MAD4;MST149;MSTP149;MAD 4;Mad4 homolog;Max associated protein 4;Max interacting transcriptional repressor MAD4;MST 149;MSTP 149;MXD 4;max dimerizer 4;OTTHUMP00000115253;max-associated protein 4;class C basic helix-loop-helix protein 12;max-interacting transcriptional repressor MAD4
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MXD4-1119H | Recombinant Human MXD4, GST-tagged | E.coli | Human | GST | 1-209aa | |
| MXD4-1599C | Recombinant Chicken MXD4 | Mammalian Cells | Chicken | His |
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| MXD4-569H | Recombinant Human MXD4 Protein, His-tagged | E.coli | Human | His |
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| MXD4-1157HCL | Recombinant Human MXD4 cell lysate | Human | Non |
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| MXD4-5776H | Recombinant Human MXD4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| MXD4-6634HF | Recombinant Full Length Human MXD4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 58 amino acids |
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Involved Pathway
MXD4 involved in several pathways and played different roles in them. We selected most pathways MXD4 participated on our site, such as Validated targets of C-MYC transcriptional repression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MXD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Validated targets of C-MYC transcriptional repression | S100A7,ZFP36L1,NDRG1,GFI1,CLU,LGALS1,DNTT,SFXN3,TMEM126A,TMEFF2 |
Protein Function
MXD4 has several biochemical functions, for example, DNA binding,protein binding,protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MXD4 itself. We selected most functions MXD4 had, and list some proteins which have the same functions with MXD4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZNF710,ZFAND5B,CLOCK,ZFP641,ASCL1,HMBOX1,ZNF643,AGFG1,ZNF526,ZNF131 |
| protein binding | TLR3,EMD,PRH2,SIK2,ZNF155,CCDC22,C5orf13,MC5R,RBM17,TAGLN |
| transcription corepressor activity | SETD8,PSMC3,NCOR1,SAP30,NCOR2,CREG1,ALX1,CRYM,SKI,TFAP2B |
| protein dimerization activity | HES2.1,OLIG4,POLR2J2,FBXW11A,MAX,EPAS1B,HIF1AB,MSGN1,TFE3B,HELT |
Interacting Protein
MXD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MXD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MXD4.
TCP10L;Max;Trappc11
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