MXD1

  • Official Full Name

    MAX dimerization protein 1

  • Overview

    This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

  • Synonyms

    MXD1;MAX dimerization protein 1;MAD;bHLHc58;MAD1;max dimerizer 1;MAX-binding protein;antagonizer of myc transcriptional activity;MGC104659

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Chicken
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • Insect Cells
  • Wheat Germ
  • In Vitro Cell Free System
  • Non
  • Flag
  • His
  • His&Fc&Avi
  • His&Myc
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
MXD1-2502H Active Recombinant Human MAX Dimerization Protein 1 E.coli Human Non
MXD1-28856TH Recombinant Human MXD1, FLAG-tagged E.coli Human Flag Full L. 1-221 a.a.
MXD1-2913R Recombinant Rhesus monkey MXD1 Protein, His-tagged Mammalian Cells Rhesus macaque His
MXD1-3369C Recombinant Chicken MXD1 Mammalian Cells Chicken His
MXD1-427HCL Recombinant Human MXD1 lysate HEK293 Human Non
MXD1-2732R Recombinant Rhesus Macaque MXD1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
MXD1-2732R-B Recombinant Rhesus Macaque MXD1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
MXD1-2778M Recombinant Mouse MXD1 Protein (1-227 aa), His-Myc-tagged Insect Cells Mouse His&Myc 1-227 aa
MXD1-301546H Recombinant Human MXD1 protein, GST-tagged E.coli Human GST Asp170-Leu221
MXD1-5773H Recombinant Human MXD1 Protein, GST-tagged Wheat Germ Human GST
MXD1-6631HF Recombinant Full Length Human MXD1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 221 amino acids

    Involved Pathway

    MXD1 involved in several pathways and played different roles in them. We selected most pathways MXD1 participated on our site, such as Regulation of Telomerase,Signaling events mediated by HDAC Class I, which may be useful for your reference. Also, other proteins which involved in the same pathway with MXD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling events mediated by HDAC Class I FKBP3,PRMT5,SIRT2,WDR77,SIRT4,SIRT7,TFCP2,SIRT5,GATA2,NR2C1
    Regulation of Telomerase SP3,NR2F2,PINX1,CMTM2A,DKC1,TNKS

    Protein Function

    MXD1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein binding,protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MXD1 itself. We selected most functions MXD1 had, and list some proteins which have the same functions with MXD1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding FOSL2,NPAS4,MED1,POU1F1,RBPJB,ZNF713,HOXA10,RFX4,HOXD13,ISL1
    transcription factor activity, sequence-specific DNA binding DMRTA2,ZNF79,RORA,CSRNP3,DLX4,ESR2A,SOX7,UBN2A,SALL3,PRDM15
    protein dimerization activity SREBF1,MEF2CB,HER2,AHRRA,MAX,HES3,ASCL1A,HPS1,SOHLH2,MESPAB
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding TBX15,HELT,SPI1,ZFP90,ASCL2,ZFPM2,GATA3,ESRRA,SFPI1,PRDM1
    transcription cofactor activity MAX,FAM48A,MED4,AIRE,ZNF671,NFE2L1,ZMYND11,PIR,PRKCBP1L,TMF1
    protein binding PRPF4B,HERPUD1,MAP2K1,C10orf35,FATE1,EMD,USP34,IKZF1,PABPC1,CRNKL1
    transcription corepressor activity HDAC4,LHX1,BCL11A,ATF5,ZMYND11,TLE2,HOMEZA,NPAT,ZNF136,PEX14

    Interacting Protein

    MXD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MXD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MXD1.

    SIN3B;MAX;MLX

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