MUT

  • Official Full Name

    methylmalonyl CoA mutase

  • Overview

    This gene encodes the mitochondrial enzyme methylmalonyl Coenzyme A mutase. In humans, the product of this gene is a vitamin B12-dependent enzyme which catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, while in other species this enzyme may have different functions. Mutations in this gene may lead to various types of methylmalonic aciduria.

  • Synonyms

    MUT;methylmalonyl CoA mutase;methylmalonyl Coenzyme A mutase;methylmalonyl-CoA mutase, mitochondrial;mitochondrial;MCM;Methylmalonyl CoA isomerase;Methylmalonyl CoA mutase mitochondrial;Methylmalonyl-CoA isomerase;Methylmalonyl-CoA mutase;MUTA_HUMAN

Recombinant Proteins

  • Mouse
  • Rhesus macaque
  • Human
  • Zebrafish
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • E.coli
  • In Vitro Cell Free System
  • Yeast
  • His
  • Non
  • T7
  • Avi
  • Fc
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
MUT-10264M Recombinant Mouse MUT Protein Mammalian Cells Mouse His
MUT-2909R Recombinant Rhesus monkey MUT Protein, His-tagged Mammalian Cells Rhesus macaque His
MUT-30098TH Recombinant Human MUT Wheat Germ Human Non 750 amino acids
MUT-5732Z Recombinant Zebrafish MUT Mammalian Cells Zebrafish His
MUT-920H Recombinant Human MUT Mammalian Cells Human His
MUT-4054HCL Recombinant Human MUT 293 Cell Lysate HEK293 Human Non
MUT-1678H Recombinant Human MUT protein, His & T7-tagged E.coli Human His&T7 Val510~Ser749
MUT-2728R Recombinant Rhesus Macaque MUT Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
MUT-2728R-B Recombinant Rhesus Macaque MUT Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Mut-3256M Recombinant Mouse Mut protein, His-tagged E.coli Mouse His 31-748aa
MUT-329HF Recombinant Full Length Human MUT Protein In Vitro Cell Free System Human Full L. 750 amino acids
MUT-3549H Recombinant Human MUT Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
MUT-3549H-B Recombinant Human MUT Protein Pre-coupled Magnetic Beads HEK293 Human
Mut-5475M Recombinant Mouse Mut protein, His-tagged Yeast Mouse His 31-748aa
MUT-5762H Recombinant Human MUT Protein, GST-tagged Wheat Germ Human GST
MUT-5818M Recombinant Mouse MUT Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
MUT-5818M-B Recombinant Mouse MUT Protein Pre-coupled Magnetic Beads HEK293 Mouse
MUT-6579HF Recombinant Full Length Human MUT Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 750 amino acids

    Involved Pathway

    MUT involved in several pathways and played different roles in them. We selected most pathways MUT participated on our site, such as Valine, leucine and isoleucine degradation,Glyoxylate and dicarboxylate metabolism,Propanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MUT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Carbon metabolism GLDC,FBP1A,PKM,ME2,PSAT1,ECHS1,SUCLG2,HK2,ESD,HADHAB
    Valine, leucine and isoleucine degradation AOX4,ACAA1A,HADHAA,OXCT2B,AOX3L1,HMGCLL1,BCAT1,DLDH,ALDH9A1,IL4I1
    Metabolic pathways FUT8,NAMPTB,CBR1L,POLR3G,OXSR1,DOLK,ACSM4,PFKP,HMGCLL1,HPRT1
    Propanoate metabolism ACACB,HADHA,ACAT2,ACSS2L,ACACA,HADHAA,LDHBA,ackA,ACAT1,ECHDC1
    Glyoxylate and dicarboxylate metabolism AGXT,PCCB,SHMT1,MDH1,GLDC,ACO1,HYI,MDH2,HAO2,ACAT1

    Protein Function

    MUT has several biochemical functions, for example, cobalamin binding,metal ion binding,methylmalonyl-CoA mutase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MUT itself. We selected most functions MUT had, and list some proteins which have the same functions with MUT. You can find most of the proteins on our site.

    Function Related Protein
    modified amino acid binding NOX4,DPEP1,CPS1,MTHFR,CBS
    cobalamin binding TCN2,CD320,TCNL,LMBRD1,MMACHC,CUBN,GIF,TCN1
    metal ion binding COL27A1,AGFG1B,TNNI1,ALOX5B.2,KDM8,NCALDB,MFNG,MBTD1,KDM6B,TDO2B

    Interacting Protein

    MUT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MUT here. Most of them are supplied by our site. Hope this information will be useful for your research of MUT.

    PCBD1;ICT1;Esrrb

    Resources

    References

    • Ehrenschwender, M; Bittner, S; et al. XIAP-targeting drugs re-sensitize PIK3CA-mutated colorectal cancer cells for death receptor-induced apoptosis. CELL DEATH & DISEASE 5:-(2014).
    • Riegger, D; Hai, R; et al. The Nucleoprotein of Newly Emerged H7N9 Influenza A Virus Harbors a Unique Motif Conferring Resistance to Antiviral Human MxA. JOURNAL OF VIROLOGY 89:2241-2252(2015).

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