MTTP
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Official Full Name
microsomal triglyceride transfer protein -
Overview
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008] -
Synonyms
MTTP;microsomal triglyceride transfer protein;ABL;MTP;microsomal triglyceride transfer protein large subunit;microsomal triglyceride transfer protein (large polypeptide, 88kDa)
Recombinant Proteins
- Human
- Chicken
- Mouse
- Wheat Germ
- Mammalian Cells
- E.coli
- HEK293
- In Vitro Cell Free System
- GST
- His
- His&T7
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MTTP-5739H | Recombinant Human MTTP Protein, GST-tagged | Wheat Germ | Human | GST | ||
| MTTP-271H | Recombinant Human MTTP | Mammalian Cells | Human | His |
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| MTTP-3761C | Recombinant Chicken MTTP | Mammalian Cells | Chicken | His |
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| Mttp-7973M | Recombinant Mouse Mttp protein, His & T7-tagged | E.coli | Mouse | His&T7 | Leu28~Gly459 |
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| MTTP-4064HCL | Recombinant Human MTTP 293 Cell Lysate | HEK293 | Human | Non |
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| MTTP-3541H | Recombinant Human MTTP Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| MTTP-3541H-B | Recombinant Human MTTP Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| MTTP-6566HF | Recombinant Full Length Human MTTP Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 151 amino acids |
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Involved Pathway
MTTP involved in several pathways and played different roles in them. We selected most pathways MTTP participated on our site, such as Fat digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTTP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fat digestion and absorption | DGAT1,APOA1,PLA2G2A,PLA2G12B,PPAP2C,FABP2,SLC27A4,CLPS,CD36,ABCG8 |
Protein Function
MTTP has several biochemical functions, for example, lipid binding,lipid transporter activity,phospholipid transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MTTP itself. We selected most functions MTTP had, and list some proteins which have the same functions with MTTP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipid transporter activity | APOD,SLCO2A1,APOF,VTG7,VTG6,MTP,APOE,APOM,VTG4,RFT1 |
| lipid binding | APOA4B.2,FFAR1,MAL,SH3GL2,APOEA,AP2M1,APOA1B,APOA5,FABP12,RASGRP1 |
| protein heterodimerization activity | HIST1H2AG,BCL11A,TAS1R3,ATF2,HEYL,CHRAC1,H3F3A,KCNB2,ZBTB1,MYH7 |
| protein binding | FBXL14,POU3F3,REV1,DLL4,CRIPAK,MYL12A,KCTD9,RNF146,STX12,COPS5 |
| phospholipid transporter activity | CETP,ABCA1B,ABCA7,ABCG1,OSBPL5,MFSD2A,OSBPL8,MFSD2AA,ABCA13,ABCA1 |
Interacting Protein
MTTP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTTP here. Most of them are supplied by our site. Hope this information will be useful for your research of MTTP.
Resources
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References
- Sahebkar, A; Chew, GT; et al. Recent advances in pharmacotherapy for hypertriglyceridemia. PROGRESS IN LIPID RESEARCH 56:47-66(2014).
- Sahebkar, A; Watts, GF; et al. Managing recalcitrant hypercholesterolemia in patients on current best standard of care: efficacy and safety of novel pharmacotherapies. CLINICAL LIPIDOLOGY 9:221-233(2014).
