MTNR1B
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Official Full Name
melatonin receptor 1B -
Overview
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. -
Synonyms
MTNR1B;melatonin receptor 1B;melatonin receptor type 1B;mel1b receptor;melatonin receptor MEL1B;MT2;FGQTL2;MEL-1B-R
Recombinant Proteins
- Chicken
- Cynomolgus
- Xenopus laevis
- Mus musculus
- Human
- Mammalian Cells
- E.coli
- HEK293
- His
- His&GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MTNR1B-5528C | Recombinant Chicken MTNR1B | Mammalian Cells | Chicken | His |
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| MTNR1B-715C | Recombinant Cynomolgus MTNR1B Protein, His-tagged | Mammalian Cells | Cynomolgus | His |
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| MTNR1B-1143C | Recombinant Chicken MTNR1B Protein, His&GST-tagged | E.coli | Chicken | His&GST | Gly235-Leu289 |
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| MTNR1B-460C | Recombinant Cynomolgus Monkey MTNR1B Protein, His (Fc)-Avi-tagged | HEK293 | Cynomolgus | His&Fc&Avi |
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| MTNR1B-460C-B | Recombinant Cynomolgus Monkey MTNR1B Protein Pre-coupled Magnetic Beads | HEK293 | Cynomolgus |
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| RFL11136XF | Recombinant Full Length Xenopus Laevis Melatonin Receptor Type 1B(Mtnr1B) Protein, His-Tagged | E.coli | Xenopus laevis | His | Full L. Full Length (1-152) |
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| RFL34813MF | Recombinant Full Length Mouse Melatonin Receptor Type 1B(Mtnr1B) Protein, His-Tagged | E.coli | Mus musculus | His | Full L. Full Length (1-364) |
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| RFL6276HF | Recombinant Full Length Human Melatonin Receptor Type 1B(Mtnr1B) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length (1-362) |
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Involved Pathway
MTNR1B involved in several pathways and played different roles in them. We selected most pathways MTNR1B participated on our site, such as Neuroactive ligand-receptor interaction,Circadian entrainment, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTNR1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Circadian entrainment | KCNJ9,PRKACB,GRIA4,GNAS,CALM2,PRKACA,PRKG1,PRKCG,GNG13,GRIN1 |
| Neuroactive ligand-receptor interaction | GRIA4,TAAR12B,LEPR,C3AR1,GABRA1,MCHR1,GRIN1B,TAAR4,SSTR1,GRM6B |
Protein Function
MTNR1B has several biochemical functions, for example, G-protein coupled receptor activity,melatonin receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTNR1B itself. We selected most functions MTNR1B had, and list some proteins which have the same functions with MTNR1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| melatonin receptor activity | MTNR1A,MTNR1BA,MTNR1C,MTNR1AL,MTNR1AA,MTNR1BB,GPR50 |
| G-protein coupled receptor activity | VMN2R116,TAAR14F,FZD9B,OR2AP1,OR115-6,TAS2R118,GPR119,OR4F29,LPAR3,OR6B2 |
| protein binding | NUCB2,TMED10,RNF113A,MIA3,ANKMY2,REEP5,TSSK3,MAGED1,MTOR,SPATA24 |
Interacting Protein
MTNR1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTNR1B here. Most of them are supplied by our site. Hope this information will be useful for your research of MTNR1B.
RGS20;MTNR1A;IRS4;PPM1G;GNAI2;GNAI3;HSPA5;FLNA;YWHAQ;CANX;PI4KA;COPA;GNB2;GNAI1;PDIA6;P4ha2;VPS35;GNB4
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References
- Winkler, C; Raab, J; et al. Lack of Association of Type 2 Diabetes Susceptibility Genotypes and Body Weight on the Development of Islet Autoimmunity and Type 1 Diabetes. PLOS ONE 7:-(2012).
