MTM1
-
Official Full Name
myotubularin 1 -
Overview
This gene encodes a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It is required for muscle cell differentiation and mutations in this gene have been identified as being responsible for X-linked myotubular myopathy. -
Synonyms
MTM1;myotubularin 1;myotubular myopathy 1;myotubularin;CNM;MTMX;XLMTM
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Rat
- S.cerevisiae
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
MTM1 involved in several pathways and played different roles in them. We selected most pathways MTM1 participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phosphatidylinositol signaling system | CALM1A,PIP4K2C,INPP4A,PRKCA,PIP5K1C,MTMR7,PIK3C3,PPIP5K1,IP6K3,PIP5K1BB |
| Metabolic pathways | NDUFS2,PAFAH1B1,TPH1B,MAT2AB,NT5C3A,ACADSB,UAP1,AOX3L1,HKDC1,CYP2C54 |
| Inositol phosphate metabolism | PLCD1B,MTMR7B,IPPK,NUDT4,ITPKA,INPP4AB,PIP5K1B,PIP4K2B,MINPP1B,MTMR7A |
Protein Function
MTM1 has several biochemical functions, for example, intermediate filament binding,phosphatidylinositol binding,phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MTM1 itself. We selected most functions MTM1 had, and list some proteins which have the same functions with MTM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine phosphatase activity | PTENA,SSH2,DUSP19,SSH2B,PTPN9,DUSP22B,DUSP10,CDC14B,MTMR1B,UBASH3B |
| phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity | MTMR1A,MTMR3,MTMR1,TENC1,CTDSPL2A,MTMR8,SACM1LA,SACM1L,MTMR1B,NT5DC3 |
| protein binding | CTC1,ATP2C2,BUD31,HTT,FGFR3,EPM2AIP1,TRIAP1,PTPN7,TRPC4,PPP2R5E |
| intermediate filament binding | EVPLA,EVPL,PKP2,NES,SYNM,PKP1,NME2 |
| phosphatidylinositol binding | SNX32,NOXO1A,SNX13,SNX9A,PIK3C2B,TULP4,WDR35,ESYT2,HIP1RB,SNX17 |
| phosphoprotein phosphatase activity | PPP1CC,PPP3CB,PTPREB,PPTC7,PPP5C,PPM1BB,PTPRK,PPM1BA,DUSP16,PPM1H |
| phosphatidylinositol-3-phosphatase activity | MTMR8,MTMR1A,MTMR2,PTEN,FIG4,SACM1L,MTMR3,MTMR14,MTMR1,MTMR1B |
Interacting Protein
MTM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MTM1.
DES;MTMR12;BIN1
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