MTIF3
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Official Full Name
mitochondrial translational initiation factor 3 -
Overview
This gene encodes a translation initiation factor that is involved in mitochondrial protein synthesis. Polymorphism in this gene is associated with the onset of Parkinsons disease. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5. -
Synonyms
MTIF3;mitochondrial translational initiation factor 3;translation initiation factor IF-3, mitochondrial;IF 3mt;IF3(mt);IF 3;IF3;IF3Mt;Mt;Translation initiation factor IF 3, mitochondrial precursor;IF-3(Mt)
Recombinant Proteins
- Chicken
- Human
- Mouse
- Mammalian Cells
- HEK293
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- GST
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MTIF3-5158C | Recombinant Chicken MTIF3 | Mammalian Cells | Chicken | His |
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| MTIF3-5159C | Recombinant Chicken MTIF3 | Mammalian Cells | Chicken | His |
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| MTIF3-4079HCL | Recombinant Human MTIF3 293 Cell Lysate | HEK293 | Human | Non |
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| MTIF3-2150H | Recombinant Human MTIF3 Protein (1-278 aa), GST-tagged | E.coli | Human | GST | 1-278 aa |
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| Mtif3-4213M | Recombinant Mouse Mtif3 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| MTIF3-5708H | Recombinant Human MTIF3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| MTIF3-6127H | Recombinant Human MTIF3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| MTIF3-6531HF | Recombinant Full Length Human MTIF3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 278 amino acids |
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Involved Pathway
MTIF3 involved in several pathways and played different roles in them. We selected most pathways MTIF3 participated on our site, such as Mitochondrial translation,Mitochondrial translation initiation,Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTIF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Organelle biogenesis and maintenance | RAB3IP,CEP97,MTERF,BBS12,IFT22,MRPS22,WDR35,MRPL51,POLRMT,FBF1 |
| Mitochondrial translation | MRPS27,MTFMT,MRPL54,MRPS33,AURKAIP1,MRPL55,ICT1,MRPL38,MRPL48,GADD45GIP1 |
| Mitochondrial translation initiation | MRPL38,DAP3,MRPS26,MRPS28,MRPS25,MTFMT,MRPL10,MRPS33,MRPL48,MRPL50 |
Protein Function
MTIF3 has several biochemical functions, for example, protein binding,ribosomal small subunit binding,translation factor activity, RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTIF3 itself. We selected most functions MTIF3 had, and list some proteins which have the same functions with MTIF3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ribosomal small subunit binding | PIM1,ERAL1,NPM1,DDX3X,PTCD3,NME1,DHX29,CPEB2 |
| translation factor activity, RNA binding | EIF4E2,CPEB1B,GTF2H3,CPEB4,EIF5,EIF4G1,EEF2K,EIF2S3,EIF4G3,EIF4A1 |
| translation initiation factor activity | EIF1AXA,EIF3EB,EIF3S10,EIF4G1,EIF4E1C,EIF3HB,EIF5B,EIF1AX,EIF4A1A,EIF4H |
| protein binding | THAP10,EIF2B2,GPR143,CLIC2,OTOF,ARMC2,LDHB,RAI1,BMX,FUBP3 |
Interacting Protein
MTIF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTIF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MTIF3.
SIAH1;MAPK1;2_aha_camp
Resources
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References
- Niu, YN; Liu, QQ; et al. Alternative Messenger RNA Splicing of Autophagic Gene Beclin 1 in Human B-cell Acute Lymphoblastic Leukemia Cells. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 15:2153-2158(2014).
- Schwer, CI; Stoll, P; et al. Carbon monoxide releasing molecule-2 CORM-2 represses global protein synthesis by inhibition of eukaryotic elongation factor eEF2. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 45:201-212(2013).
