MTHFD2L
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Official Full Name
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -
Synonyms
MTHFD2L;methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like;probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2;MGC72244;MTHFD2-like;NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein;FLJ131
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- E.coli
- Mammalian Cell
- Mammalian cells
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Flag
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
MTHFD2L involved in several pathways and played different roles in them. We selected most pathways MTHFD2L participated on our site, such as One carbon pool by folate,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTHFD2L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| One carbon pool by folate | AMT,DHFRL1,MTFMT,ALDH1L1,TYMS,MTHFD1L,GART,ATIC,MTHFR,MTHFS |
| Metabolic pathways | LPCAT4,POLR2GL,MAN1A,EPHX2,FUT8A,CYP24A1,CYP2C45,FECH,AK7,AMDHD1 |
Protein Function
MTHFD2L has several biochemical functions, for example, NOT formate-tetrahydrofolate ligase activity,methenyltetrahydrofolate cyclohydrolase activity,methylenetetrahydrofolate dehydrogenase (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MTHFD2L itself. We selected most functions MTHFD2L had, and list some proteins which have the same functions with MTHFD2L. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| methylenetetrahydrofolate dehydrogenase (NAD+) activity | MTHFD1,MTHFD2 |
| methenyltetrahydrofolate cyclohydrolase activity | MTHFD2,MTHFD1B,MTHFD1 |
| methylenetetrahydrofolate dehydrogenase (NADP+) activity | MTHFD2,MTHFD1,MTHFD1B |
| NOT formate-tetrahydrofolate ligase activity | MTHFD2 |
Interacting Protein
MTHFD2L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTHFD2L here. Most of them are supplied by our site. Hope this information will be useful for your research of MTHFD2L.
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References
- Appling, DR; et al. Enzymology of Mammalian Mitochondrial One-Carbon Metabolism. PTERIDINES 20:102-108(2009).
- Marttinen, P; Pirinen, M; et al. Assessing multivariate gene-metabolome associations with rare variants using Bayesian reduced rank regression. BIOINFORMATICS 30:2026-2034(2014).
- Shin, M; Bryant, JD; et al. Mitochondrial MTHFD2L Is a Dual Redox Cofactor-specific Methylenetetrahydrofolate Dehydrogenase/Methenyltetrahydrofolate Cyclohydrolase Expressed in Both Adult and Embryonic Tissues. JOURNAL OF BIOLOGICAL CHEMISTRY 289:15507-15517(2014).
- Bolusani, S; Young, BA; et al. Mammalian MTHFD2L Encodes a Mitochondrial Methylenetetrahydrofolate Dehydrogenase Isozyme Expressed in Adult Tissues. JOURNAL OF BIOLOGICAL CHEMISTRY 286:5166-5174(2011).
