MTHFD1
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Official Full Name
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -
Overview
This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. -
Synonyms
MTHFD1;methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase;MTHFC, MTHFD;C-1-tetrahydrofolate synthase, cytoplasmic;5,10 methylenetetrahydrofolate dehydrogenase 5,10 methylenetetrahydrofolate cyclohydrolase,10 formyltetrahydrofolate synthetase;C1 tetrahydrofolate synthase cytoplasmic;C1 THF synthase;C1-THF synthase;C1TC;C1TC_HUMAN;Cytoplasmic C 1 tetrahydrofolate synthase;Formyltetrahydrofolate synthetase;Methenyltetrahydrofolate cyclohydrolase;Methylenetetrahydrofolate dehydrogenase (NADP+ dependent)methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthetase;Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthetase;Methylenetetrahydrofolate dehydrogenase;MTHFC;MTHFD;NADP dependent cyclohydrolase formyltetrahydrofolate synthetase;OTTHUMP00000180657;OTTHUMP00000245366;cytoplasmic C-1-tetrahydrofolate synthase;5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase
Recombinant Proteins
- Human
- Chicken
- Rat
- Pongo Abelii
- Mouse
- Wheat Germ
- Mammalian Cells
- HEK293
- E.coli
- In Vitro Cell Free System
- Non
- His
- His&Fc&Avi
- His&SUMO
- Myc&DDK
- Flag
- GST
Involved Pathway
MTHFD1 involved in several pathways and played different roles in them. We selected most pathways MTHFD1 participated on our site, such as One carbon pool by folate,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTHFD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | MGAT5,COX4I2,NADKD1,Nat3,DCTPP1,ANPEPB,GPIB,ST3GAL5,LIPG,PRODH |
| One carbon pool by folate | FTCD,DHFRL1,MTHFD2,AMT,GART,MTHFD2L,MTHFR,ALDH1L2,MTFMT,ST20-MTHFS |
Protein Function
MTHFD1 has several biochemical functions, for example, ATP binding,formate-tetrahydrofolate ligase activity,methenyltetrahydrofolate cyclohydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MTHFD1 itself. We selected most functions MTHFD1 had, and list some proteins which have the same functions with MTHFD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| methylenetetrahydrofolate dehydrogenase (NADP+) activity | MTHFD2,MTHFD2L,MTHFD1B |
| methenyltetrahydrofolate cyclohydrolase activity | MTHFD2L,MTHFD1B,MTHFD2 |
| formate-tetrahydrofolate ligase activity | MTHFD1B,MTHFD1L |
| ATP binding | NEK12,RUNX2,CAMK2D2,RAD50,PLK1,DDX19,MYO1F,P2RX8,NMNAT3,NOD1 |
| methylenetetrahydrofolate dehydrogenase (NAD+) activity | MTHFD2,MTHFD2L |
Interacting Protein
MTHFD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTHFD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MTHFD1.
GH1;MCC;CDK2;HLA-B;ARF6;CCNA1;WRAP73;TNFRSF10D;TNIK;TRAF6;ypgR;ere_dna;Cbx4;GABARAP;HSP90AB1;MME;VCAM1
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References
- KIRK, CD; IMESON, HC; et al. THE AFFINITY OF PEA COTYLEDON 10-FORMYLTETRAHYDROFOLATE SYNTHETASE FOR POLYGLUTAMATE SUBSTRATES. PHYTOCHEMISTRY 35:291-296(1994).
- KIRK, CD; CHEN, LF; et al. A 5,10-METHYLENETETRAHYDROFOLATE DEHYDROGENASE - 5,10-METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE PROTEIN FROM PISUM-SATIVUM. PHYTOCHEMISTRY 39:1309-1317(1995).
