MTF1
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Official Full Name
metal-regulatory transcription factor 1 -
Overview
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). -
Synonyms
MTF1;metal-regulatory transcription factor 1;metal regulatory transcription factor 1;Metal response element binding transcription factor 1;MRE binding transcription factor;MRE-binding transcription factor;MTF1_HUMAN;Transcription factor MTF-1;Transcription factor MTF1;OTTHUMP00000004731;zinc regulatory factor;MRE-binding transcription factor-1;metal-responsive transcription factor 1;ZRF;MTF-1
Recombinant Proteins
- Mouse
- Rhesus macaque
- Chicken
- Human
- Zebrafish
- Mammalian Cells
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- His&T7
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
MTF1 involved in several pathways and played different roles in them. We selected most pathways MTF1 participated on our site, such as Activation of gene expression by SREBF (SREBP),Fatty acid, triacylglycerol, and ketone body metabolism,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PPARA activates gene expression | MED21,PLIN2,TIAM2,MED18,MED22,CDK19,GRHL1,MED7,ANKRD1,CTGF |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | PLIN2,MED9,CDK19,MED21,GLIPR1,MED20,MED18,MED23,MED25,MED16 |
| Regulation of cholesterol biosynthesis by SREBP (SREBF) | PMVK,NFYAL,SREBF2,NFYBA,YY2,INSIG1,DHCR7,INSIG2,NFYBB |
| Metabolism | ACOT11,ACOT6,AFMID,NDOR1,PDK2B,CDK19,OAZ3,ISCUB,GLYATL1,SLC16A1 |
| Metabolism of lipids and lipoproteins | MED16,CEPT1,MED18,PLD6,NEU3,APOA4A,GGTLC1,LPA,FAAH2A,ARSK |
| Fatty acid, triacylglycerol, and ketone body metabolism | ELOVL1A,MED15,CYP7A1,ACOT6,ECI1,MED25,CDK19,TMEM195,CYP4A11,ACOT9.2 |
| Activation of gene expression by SREBF (SREBP) | PMVK,NFYBB,CARM1,CREBBP,CYP51A1,SREBF2,DHCR7,HELZ2,NFYBA,NFYAL |
Protein Function
MTF1 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTF1 itself. We selected most functions MTF1 had, and list some proteins which have the same functions with MTF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CNIH4,IGHMBP2,ATP7B,ZNF124,TAP1,PPP2R1A,MAGEA2B,SKA1,ORM1,MAPK11 |
| metal ion binding | TRIM35-20,DYTN,BMX,NDUFS7,ATP2A3,C6AST1,ZC3H11A,ZNF786,NADK,ZNF521 |
| transcription factor activity, sequence-specific DNA binding | KLF12,ARNT,SIM1,FOXN4,CSDA,NKX2,ATF4,ZFP14,ZKSCAN3,CREBZF |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | SMAD1,TGIF1,TFE3A,RFX1,ALS2CR8,IRF1,NKX3-2,NR2C1,POU3F2,GRHL1 |
| DNA binding | PCGF2,DHX58,HIST1H4H,ZNF254,POLR2E,THRB,H2BFWT,ADNP2,ZNF582,APP |
| histone acetyltransferase binding | TRP53,GLI3,TP53,EID1,NR4A3,ZBTB7A,TRIP4,PAX6,PCNA,SP1 |
| core promoter binding | INSM1A,HDAC6,EP300,SFPI1,MYOD1,RBMX,MTA1,PSPC1,HMGA2,FOXP3 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | SFPI1,HOXA10,BSX,SIX1,CARF,OTX1,MEIS3,MEF2A,SREBF1,GRHL1 |
| transcription coactivator activity | MNT,HSF2,PDLIM1,ASXL1,TGFB1I1,SERTAD2,SMARCD1,GTF2A2,SUPT7L,MLL5 |
Interacting Protein
MTF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MTF1.
AP1M1
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References
- Bi, YY; Lin, GX; et al. Superinduction of metallothionein I by inhibition of protein synthesis: Role of a labile repressor in MTF-1 mediated gene transcription. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY 20:57-68(2006).
- Lee, CH; Jang, SH; et al. Production and characterization of monoclonal antibodies to yeast mitochondrial RNA polymerase specificity factor. JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 31:607-610(1998).
