MSX2
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Official Full Name
msh homeobox 2 -
Overview
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008] -
Synonyms
MSX2;msh homeobox 2;FPP;MSH;PFM;CRS2;HOX8;PFM1;homeobox protein MSX-2;msh homeo box 2;homeobox protein Hox-8;msh homeobox homolog 2
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Chicken
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
- GST
Involved Pathway
MSX2 involved in several pathways and played different roles in them. We selected most pathways MSX2 participated on our site, such as HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | KRAS,ANAPC7,SMAD3,WNT8B,RB1,SPI1,SRF,MAP3K3,VAC14,ATF3 |
Protein Function
MSX2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MSX2 itself. We selected most functions MSX2 had, and list some proteins which have the same functions with MSX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | SMARCD3,RARA,H2-AB1,NAAA,HIF1A,CCND1,TNFRSF10A,ARNT,KEAP1B,ARHGEF2 |
| transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | KLF12,ETV6,ARHGAP35,ESX1,BCL6A,HOXD9,VAX1,PCGF6,CGGBP1,ZBTB12.2 |
| protein binding | CTAG1B,ARPC5,RNF14,ZNF622,WIBG,CRY2,SPTSSA,NDRG4,DHDDS,OFCC1 |
| transcription regulatory region DNA binding | AHR,ARID5B,GABPA,CTCFL,TFAP4,SMAD6,SMARCA2,SNCA,TCF7,IKZF1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | STAT3,GATA4,ZIC3,KCNIP3,RFX1A,ZFP639,TGIF1,RAX,BCL11B,PHOX2B |
| transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding | MSX1,ATF3,ARNTL,CLOCK,HIST2H3A,DDN,ARNTL2,RBPJL,FOS,SNAI3 |
| transcription cofactor activity | BTG1,MED14,CALCOCO1,MED30,ZNF763,TFDP2,PRKCBP1L,TRIP13,NRG1,MED13 |
| sequence-specific DNA binding | SIX2B,POUV,LHX2A,KLF2,IRX6A,ZNF205,RARGA,VENTX,LEF1,RXRAA |
Interacting Protein
MSX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MSX2.
ATXN1
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References
- Rong, S; Zhao, XZ; et al. Vascular Calcification in Chronic Kidney Disease is Induced by Bone Morphogenetic Protein-2 via a Mechanism Involving the Wnt/beta-Catenin Pathway. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 34:2049-2060(2014).
- Zhou, LM; Matsumura, H; et al. Protamine stimulates bone sialoprotein gene expression. GENE 516:228-237(2013).
