MSX1
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Official Full Name
msh homeobox 1 -
Overview
Msh homeobox 1 (Msx1) is a Muscle Segment Homeobox (Msh) gene family member that acts as a transcriptional repressor during embryonic development, playing an important role in limb pattern formation, craniofacial development, and tooth development. Msx1 i -
Synonyms
MSX1;msh homeobox 1;HOX7, msh (Drosophila) homeo box homolog 1 (formerly homeo box 7) , msh homeobox homolog 1 (Drosophila);homeobox protein MSX-1;HYD1;OFC5;homeobox 7;msh homeo box 1;homeobox protein Hox-7;msh homeobox homolog 1;msh homeobox
Recombinant Proteins
- Mouse
- Rhesus macaque
- Chicken
- Human
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
MSX1 involved in several pathways and played different roles in them. We selected most pathways MSX1 participated on our site, such as HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | ATF1,PIK3CA,WNT1,ICAM1,RELB,FZD1,HLA-DMB,HLA-DRA,SLC25A5,AKT1 |
Protein Function
MSX1 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,p53 binding,transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MSX1 itself. We selected most functions MSX1 had, and list some proteins which have the same functions with MSX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | VAX1,SATB1,NFKB1,ZNF350,FEZF2,AEBP1,NR2F6,E2F7,CHCHD3,MSX2 |
| transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding | FOSL1A,IRF7,CLOCK,ATF3,FOSL1,RBPJL,FOS,JDP2,FOSB,SREBF1 |
| RNA polymerase II regulatory region sequence-specific DNA binding | BARX2,CDX1A,SUV39H1,ZNF548,PKNOX2,ZFY1,MEF2C,AEBP1,DBP,GATA1A |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | TRP53,NEUROD2,MAFBB,MYF5,GLIS1,CSRNP3,IRF2,FOXC1,DMRT1,BARHL1B |
| p53 binding | CHD8,SMARCB1,BANP,BRD7,SMYD2,ZMAT3,PSME3,TRIAP1,ZFP385C,CDK5 |
Interacting Protein
MSX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MSX1.
MED19;NMNAT1;ING4;PTBP3
Resources
Research Area
Apoptosis Transcription Factors and RegulatorsEpithelial Stem Cell Transcription Factors
Neural Stem Cell Transcription Factors
Neural Stem Cell Markers
Neuronal Lineage Markers
Ectodermal Lineage Markers
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References
- Sajan, SA; Rubenstein, JLR; et al. Identification of direct downstream targets of Dlx5 during early inner ear development. HUMAN MOLECULAR GENETICS 20:1262-1273(2011).
- Houpis, CH; Tosios, KI; et al. Parathyroid hormone-related peptide (PTHrP), parathyroid hormone/parathyroid hormone-related peptide receptor 1 (PTHR1), and MSX1 protein are expressed in central and peripheral giant cell granulomas of the jaws. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY 109:415-424(2010).
