MSI2
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Official Full Name
musashi homolog 2 -
Overview
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Two transcript variants encoding distinct isoforms have been identified for this gene. -
Synonyms
MSI2;musashi homolog 2 (Drosophila);RNA-binding protein Musashi homolog 2;musashi-2;MSI2H;MGC3245;FLJ36569
Recombinant Proteins
- Human
- Mouse
- E.coli
- HEK293
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
- Flag
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MSI2-1115H | Recombinant Human MSI2, GST-tagged | E.coli | Human | GST | 1-328aa | |
| MSI2-225H | Recombinant Human musashi RNA-binding protein 2, His-tagged | E.coli | Human | His | 1-328 a.a. |
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| MSI2-4115HCL | Recombinant Human MSI2 293 Cell Lysate | HEK293 | Human | Non |
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| MSI2-1441H | Recombinant Human MSI2 Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| MSI2-1441H-B | Recombinant Human MSI2 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| MSI2-386HFL | Recombinant Full Length Human MSI2 Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| Msi2-4189M | Recombinant Mouse Msi2 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| MSI2-4221H | Recombinant Human MSI2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| MSI2-5654H | Recombinant Human MSI2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| MSI2-6562HF | Recombinant Full Length Human MSI2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 328 amino acids |
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Involved Pathway
MSI2 involved in several pathways and played different roles in them. We selected most pathways MSI2 participated on our site, such as mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA surveillance pathway | CPSF7,PAPOLB,PPP2R2BB,WIBG,CPSF1,GSPT1L,WDR33,PABPC3,DAZAP1,MSI1 |
Protein Function
MSI2 has several biochemical functions, for example, nucleotide binding,poly(A) RNA binding,poly(U) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MSI2 itself. We selected most functions MSI2 had, and list some proteins which have the same functions with MSI2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | RPS11,NMD3,NCL,SNRNP200,RPL10L,DCAF13,RPL26,TRIP6,TIA1,RPL7 |
| poly(U) RNA binding | MSI1,KHDRBS2,DIS3L2,KHDC1A,HNRNPC,RBM11,PABPC4,KHDRBS1,HNRNPH1,PNPT1 |
| nucleotide binding | SRSF6A,MAGI1,SPATA5,CPEB3,PRKACAB,GUCY2F,MTIF2,HNRNPC,SMYHC3,UCK2B |
| protein binding | C3orf52,SF1,DOCK9,LRRIQ3,HSPD1,NUDCD2,C9orf100,IPO13,C1QB,COL6A5 |
Interacting Protein
MSI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MSI2.
MEOX2;HNRNPH2;GRB2;SF1;pre-let-7a;CDK1;H2AFX;VCAM1;KIF21A
Resources
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References
- Gunter, KM; McLaughlin, EA; et al. Translational Control in Germ Cell Development: A Role for the RNA-Binding Proteins Musashi-1 and Musashi-2. IUBMB LIFE 63:678-685(2011).
- Yokota, N; Mainprize, TG; et al. Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization. ONCOGENE 23:3444-3453(2004).
