MSH5
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Official Full Name
mutS homolog 5 -
Overview
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. -
Synonyms
MSH5;mutS homolog 5 (E. coli);mutS (E. coli) homolog 5;mutS protein homolog 5;G7;NG23;MUTSH5;MGC2939;DKFZp434C1615
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MSH5-3844H | Recombinant Human MSH5 protein, His-tagged | E.coli | Human | His | 635-835 aa | |
| MSH5-3788R | Recombinant Rat MSH5 Protein | Mammalian Cells | Rat | His |
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| MSH5-4118HCL | Recombinant Human MSH5 293 Cell Lysate | HEK293 | Human | Non |
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| MSH5-1240H | Recombinant Human MSH5 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| MSH5-2013H | Recombinant Human MSH5 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| MSH5-3447R | Recombinant Rat MSH5 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| MSH5-3447R-B | Recombinant Rat MSH5 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Msh5-4187M | Recombinant Mouse Msh5 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| MSH5-5652H | Recombinant Human MSH5 Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
MSH5 involved in several pathways and played different roles in them. We selected most pathways MSH5 participated on our site, such as Cell Cycle,Meiosis,Meiotic recombination, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSH5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ovarian Infertility Genes | ZP2,ZP3,DAZL,NR5A1,SYNE2,DMC1,NRIP1,INHA,GJA4 |
| Meiosis | TINF2,MND1,TEX15,SUN1,TEX12,SYCE1,SYNE1,DIDO1,SPO11,PSMC3IP |
| Meiotic recombination | TEX15,MSH4,MND1,SPO11,PSMC3IP,DMC1 |
| Cell cycle | CCNB3,MCM6L,SPO11,CSNK1E,TUBB4A,NUPL2,CCND3,CDC7,SGOL2,NDEL1 |
Protein Function
MSH5 has several biochemical functions, for example, ATP binding,DNA-dependent ATPase activity,NOT damaged DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MSH5 itself. We selected most functions MSH5 had, and list some proteins which have the same functions with MSH5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mismatched DNA binding | PMS1,MLH1,TDG,MSH6,MSH4,MLH3 |
| ATP binding | IPPK,ATP8A1,ERCC6L2,AURKC,WRNIP1,TSSK6,PRKCA,HIPK1,CSNK1G2,CSNK1A1L |
| NOT damaged DNA binding | MSH4 |
| protein binding | PHLPP1,TRAF6,CENPW,RNF220,PSMC2,SUPV3L1,STXBP2,INCA1,PAIP1,METTL17 |
| DNA-dependent ATPase activity | CDK7,MSH6,XRCC3,IGHMBP2,RAD51L1,MSH2,DHX36,XRCC2,DDX11,TOP2A |
Interacting Protein
MSH5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSH5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MSH5.
ABL1;MSH4;XRCC5;Brca1;Tecpr2;LRRK2;SGTB
Resources
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References
- Skeldon, SC; Semotiuk, K; et al. Patients with Lynch Syndrome Mismatch Repair Gene Mutations Are at Higher Risk for Not Only Upper Tract Urothelial Cancer but Also Bladder Cancer. EUROPEAN UROLOGY 63:379-385(2013).
- Aceto, GM; De Lellis, L; et al. Nonfluorescent Denaturing HPLC-Based Primer-Extension Method for Allele-Specific Expression: Application to Analysis of Mismatch Repair Genes. CLINICAL CHEMISTRY 55:1711-1718(2009).
