MRPL28
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Official Full Name
mitochondrial ribosomal protein L28 -
Overview
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion. -
Synonyms
MRPL28;mitochondrial ribosomal protein L28;MAAT1, melanoma associated antigen recognised by cytotoxic T lymphocytes;39S ribosomal protein L28, mitochondrial;p15;39S ribosomal protein L28 mitochondrial;39S ribosomal protein L28 mitochondrial precursor;HGNC6756;L28mt;MAAT 1;MAAT1;Melanoma antigen p15;Melanoma associated antigen recognised by cytotoxic T lymphocytes;Melanoma associated antigen recognized by T lymphocytes;MGC8499;MRP L28;MRPL 28;MRP-L28;melanoma-associated antigen recognized by T lymphocytes;melanoma-associated antigen recognised by cytotoxic T lymphocytes
Recombinant Proteins
- Mouse
- Zebrafish
- Chicken
- Human
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- T7
- Non
- Myc&DDK
- GST
- His&Fc&Avi
Involved Pathway
MRPL28 involved in several pathways and played different roles in them. We selected most pathways MRPL28 participated on our site, such as Mitochondrial translation,Mitochondrial translation elongation,Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL28 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitochondrial translation | MRPL10,MRPL48,TSFM,MRPS25,TUFM,PTCD3,GFM1,ICT1,MRPS26,MRPL39 |
| Ribosome | UBA52,MRPS11,RPS4X,RPL34,MRPS12,RPL27A,MRPL19,MRPL32,RPS5,MRPL30 |
| Organelle biogenesis and maintenance | BBS9,TSFM,TCTEX1D2,EXOC1,TUFM,GFM2,IFT43,GFM1,RP2,DYNLRB1 |
| Mitochondrial translation elongation | TUFM,MRPL49,MRPS26,AURKAIP1,MRPL45,MRPS31,GADD45GIP1,MRPS23,MRPL54,MRPL38 |
| Mitochondrial translation termination | MRPL3,MRPL42,MRPS24,MRPS26,MRPL54,MTRF1L,MRPL51,AURKAIP1,MRPL48,MRRF |
| Mitochondrial translation initiation | MRPL42,MRPS23,MRPL54,MRPL38,MRPL44,MRPL53,MRPS25,MTFMT,PTCD3,MRPL50 |
Protein Function
MRPL28 has several biochemical functions, for example, poly(A) RNA binding,protein binding,structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL28 itself. We selected most functions MRPL28 had, and list some proteins which have the same functions with MRPL28. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural constituent of ribosome | RPL27A,RPL36AL,MRPL27,MRPL16,RPS27L,RPSA,RPS12,MRPL4,MRPS16,MRPS30 |
| protein binding | HIST1H2AM,ZNF559-ZNF177,MTIF3,ARMC2,CINP,TTC5,WASL,YIPF4,ATP5B,RASSF4 |
| poly(A) RNA binding | P4HB,ELAVL1,RTCD1,IPO5,NHP2,FDPS,CLTC,DHX37,GM5506,SNRPG |
Interacting Protein
MRPL28 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL28 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL28.
TRAF3IP2;CDR2;TEF;HMBOX1;FAM9B;BANP;TRAF4
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References
- Yang, YR; Jian, W; et al. Characterization of TsMRP-L28, a mitochondrial ribosomal protein L28 from the parasitic nematode Trichinella spiralis. GENE 512:496-504(2013).
- Wierschke, S; Gigout, S; et al. Evaluating reference genes to normalize gene expression in human epileptogenic brain tissues. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 403:385-390(2010).
