MRPL12
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Official Full Name
mitochondrial ribosomal protein L12 -
Overview
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. -
Synonyms
MRPL12;mitochondrial ribosomal protein L12;RPML12;39S ribosomal protein L12, mitochondrial;MRPL7;MRPL7/L12;MRP-L12;5c5-2;L12mt;MRP-L31/34;MGC8610;FLJ60124
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Rhesus macaque
- Mammalian Cell
- HEK293
- E.coli
- HEK293T
- Mammalian cells
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
MRPL12 involved in several pathways and played different roles in them. We selected most pathways MRPL12 participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ribosome | RPL5B,RPS10,FAUA,MRPL22,RPL13A,MRPS6,RPS26L,RPS16,MRPS7,MRPL20 |
Protein Function
MRPL12 has several biochemical functions, for example, RNA binding,protein binding,structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL12 itself. We selected most functions MRPL12 had, and list some proteins which have the same functions with MRPL12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural constituent of ribosome | MRPS5,RPL37A,MRP63,MRPS21,RPS27.1,MRPS9,RPL36,RPS9,RPS2,RPS14 |
| RNA binding | IFIT10,SF3A1,THOC5,DOM3Z,RPL14,FAU,HNRNPA1,PABPC5,EIF4H,AKAP1B |
| protein binding | POLR2E,SEC13,MMP3,HBXIP,TIMM21,SF3A2,DDO,ASCL3,CDCP1,CUEDC2 |
Interacting Protein
MRPL12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL12 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL12.
ICT1;Ybx1;RELA;IKBKE;NOA1;RARG;COX6A2;OLIG1;TMEM51;POLR1D;ssrna_ug;Smad6;C1qbp;NS;YBX1;PPP2R2B;MRPL50
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