MRPL10
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Official Full Name
mitochondrial ribosomal protein L10 -
Overview
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. -
Synonyms
MRPL10;mitochondrial ribosomal protein L10;39S ribosomal protein L10, mitochondrial;39S ribosomal protein L10;mitochondrial;L10MT;MGC17973;MRP L8;MRP L10;MRPL8;RPML8;39S ribosomal protein L10 mitochondrial;39S ribosomal protein L10 mitochondrial precursor;MRPL 10;L8mt;39S ribosomal protein L8, mitochondrial;MRP-L8;MRP-L10
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Avi
- Fc
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MRPL10-977H | Recombinant Human MRPL10, His-tagged | E.coli | Human | His | 1-261aa | |
| MRPL10-2146Z | Recombinant Zebrafish MRPL10 | Mammalian Cells | Zebrafish | His |
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| MRPL10-2831R | Recombinant Rhesus monkey MRPL10 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| MRPL10-4199HCL | Recombinant Human MRPL10 293 Cell Lysate | HEK293 | Human | Non |
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| MRPL10-2651R | Recombinant Rhesus Macaque MRPL10 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| MRPL10-2651R-B | Recombinant Rhesus Macaque MRPL10 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| MRPL10-5554H | Recombinant Human MRPL10 Protein, GST-tagged | Wheat Germ | Human | GST |
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| MRPL10-6377HF | Recombinant Full Length Human MRPL10 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 261 amino acids |
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Involved Pathway
MRPL10 involved in several pathways and played different roles in them. We selected most pathways MRPL10 participated on our site, such as Mitochondrial translation,Mitochondrial translation elongation,Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ribosome | RPL10A,RPS29,RPL19,RPL7,RPS5,RPSA,RPS17L,RPL35A,RPL22,RPL34 |
| Mitochondrial translation elongation | GADD45GIP1,MRPS28,MRPS25,MRPL40,MRPL45,MRPL28,MRPL54,MRPS23,TSFM,MRPS33 |
| Mitochondrial translation initiation | MRPS25,MRPL44,MRPL45,MRPS34,MRPL53,MRPS24,MRPL40,MRPL52,MRPL42,DAP3 |
| Mitochondrial translation termination | MRPS36,MRPS35,MRPL44,MRPL28,MRPL40,GFM2,MRPS28,MRPS23,MRPL47,MRPL49 |
| Mitochondrial translation | MRPL49,CHCHD1,MRPL46,MRPS25,MRPS26,MRPS22,MRPL48,TUFM,MRPL28,MRPL39 |
| Organelle biogenesis and maintenance | TTC30A,LZTFL1,TTC26,B9D1,RABL5,SCLT1,RPGRIP1L,TTC8,ATAT1,GABPA |
Protein Function
MRPL10 has several biochemical functions, for example, poly(A) RNA binding,protein binding,structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL10 itself. We selected most functions MRPL10 had, and list some proteins which have the same functions with MRPL10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | GPATCH8,ANKRD17,U2AF2,ARF1,ESF1,NSA2,RBM27,SLTM,RPS17L,RPS19BP1 |
| protein binding | TRIP10,PTPRJ,ZBED4,MAP3K3,ZFP523,RAB6B,GRIK5,TBC1D15,CKMT1,CASP6 |
| structural constituent of ribosome | MRPL35,MRPL16,MRPS24,RPS27.2,MRPS6,MRPL1,RPS15A,RPL13,RPS2,MRPL20 |
Interacting Protein
MRPL10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL10.
TCF4;REL;KLHL12;FAM9B;PNMA1;USP22;ICT1;MRPL50;MRPL9;MRPL1
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References
- Han, MJ; Cimen, H; et al. Purification of human mitochondrial ribosomal L7/L12 stalk proteins and reconstitution of functional hybrid ribosomes in Escherichia coli. PROTEIN EXPRESSION AND PURIFICATION 78:48-54(2011).
- Koc, EC; Yang, YJ; et al. NAD plus -dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of mitochondrial ribosomal protein L10. FASEB JOURNAL 24:-(2010).
