MRE11A

  • Official Full Name

    MRE11 meiotic recombination 11 homolog A (S. cerevisiae)

  • Overview

    This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3 to 5 exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3 to 5 exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

  • Synonyms

    MRE11A;MRE11 meiotic recombination 11 homolog A (S. cerevisiae);ATLD;HNGS1;MRE11;MRE11B;double-strand break repair protein MRE11A;AT-like disease;MRE11 homolog 1;MRE11 homolog A;endo/exonuclease Mre11;meiotic recombination 11 homolog 1;meiotic recombination 11 homolog A;DNA recombination and repair protein

Recombinant Proteins

  • Human
  • Zebrafish
  • Rat
  • Chicken
  • Mouse
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His
  • Non
  • His&Fc&Avi
  • Myc&DDK
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
MRE11A-2895H Recombinant Human MRE11A protein, His-tagged E.coli Human His 170-400 aa
MRE11A-212Z Recombinant Zebrafish MRE11A Mammalian Cells Zebrafish His
MRE11A-28636TH Recombinant Human MRE11A Wheat Germ Human Non 206 amino acids
MRE11A-3748R Recombinant Rat MRE11A Protein Mammalian Cells Rat His
MRE11A-6342C Recombinant Chicken MRE11A Mammalian Cells Chicken His
MRE11A-741H Recombinant Human MRE11A Protein, His-tagged E.coli Human His
MRE11A-4211HCL Recombinant Human MRE11A 293 Cell Lysate HEK293 Human Non
MRE11A-315HF Recombinant Full Length Human MRE11A Protein In Vitro Cell Free System Human Full L. 206 amino acids
MRE11A-3407R Recombinant Rat MRE11A Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
MRE11A-3407R-B Recombinant Rat MRE11A Protein Pre-coupled Magnetic Beads HEK293 Rat
Mre11a-4136M Recombinant Mouse Mre11a Protein, Myc/DDK-tagged HEK293 Mouse Myc&DDK
MRE11A-5537H Recombinant Human MRE11A Protein, GST-tagged Wheat Germ Human GST
MRE11A-6354HF Recombinant Full Length Human MRE11A Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 206 amino acids

    Involved Pathway

    MRE11A involved in several pathways and played different roles in them. We selected most pathways MRE11A participated on our site, such as Homologous recombination,Non-homologous end-joining, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRE11A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Homologous recombination RAD54L,BRCA2,SHFM1,CDK5R2,TOP3A,RAD51L3,XRCC2,RAD51L1,RAD54B,RAD52
    Non-homologous end-joining POLM,LIG4,XRCC5,FEN1,PRKDC,DCLRE1C,DNTT,XRCC6,XRCC4,NHEJ1

    Protein Function

    MRE11A has several biochemical functions, for example, 3-5 exonuclease activity,contributes_to ATP-dependent DNA helicase activity,contributes_to DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MRE11A itself. We selected most functions MRE11A had, and list some proteins which have the same functions with MRE11A. You can find most of the proteins on our site.

    Function Related Protein
    endonuclease activity CENPT,DCLRE1C,RNASE3,PMS2,APEX1,RNASEL4,RSFR,ENDOU2,RNASEL3,EAR1
    contributes_to DNA binding MAFGA,TCF3,FOXH1,MCM7,GTF3C4,MAFGB,CLOCKA,GTF3C5,SMAD2,MLXIPL
    protein C-terminus binding DLG3,PCGF1,EFHC1,ERCC4,BCAM,GRIP1,CTGF,COIL,JAK2,ATXN2
    protein binding TMEM182,GLI1,SCP2,CARD8,TCEAL5,LRRC4B,PSMD9,SUCLA2,GNA13,CDIPT
    3-5 exonuclease activity REXO2,APLF,TREX1,RAD9A,RAD9,ERI1,EXOSC10,REV3L,POLE,EXD1
    endodeoxyribonuclease activity DNASE1L2,ZRANB3,ERCC5,RPS3,DNASE2A,DNASE1,ERCC4,DNASE1L1,APLF,APEX1
    single-stranded DNA endodeoxyribonuclease activity SETMAR,RBBP8,DCLRE1C,ERCC4
    contributes_to ATP-dependent DNA helicase activity MCM7,RAD50,NBN,MCM4,MCM6
    nuclease activity REXO1,EXO5,ENDOU2,USB1,HARBI1,EAR4,SMG6,RAG1,EAR1,MEIOB

    Interacting Protein

    MRE11A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRE11A here. Most of them are supplied by our site. Hope this information will be useful for your research of MRE11A.

    H2AFX;FANCD2;MDC1

    Resources

    Research Area

    G2/M (DNA Damage) Checkpoints

    References

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