MRAS
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Official Full Name
muscle RAS oncogene homolog -
Overview
This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
MRAS;muscle RAS oncogene homolog;ras-related protein M-Ras;M RAs;R RAS3;RRAS3;FLJ42964;M-ras;Muscle and microspikes Ras;Muscle Ras oncogene homologue;R-ras3;Ras related protein MRas;Ras related protein RRas3;Ras-related protein R-Ras3;RASM_HUMAN;XRas
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- DDK
- Myc
- Avi
- Fc
- GST
Involved Pathway
MRAS involved in several pathways and played different roles in them. We selected most pathways MRAS participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRAS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phospholipase D signaling pathway | AVPR1B,RAF1,AGPAT4,MTOR,KRAS,SHC1,PLCG1,PPAP2C,DGKE,AVPR1A |
| HTLV-I infection | WNT5B,HLA-DOA,SLC2A1,NFATC1,MYBL2,HLA-DPB1,PTTG2,MAP3K3,CD3E; CD3D,TGFBR2 |
| Ras signaling pathway | RASA1,FGF2,PLA2G4A,PRKCA,NF1,ETS2,FGF20,KLK1B4,GNB1,PRKCG |
| MAPK signaling pathway | HSPA1B,AKT3A,AKT2L,RAP1B,FGF8A,CACNG7,FGF9,NRAS,IL1A,NTRK2B |
| Regulation of Actin Cytoskeleton | NRAS,FGF9,ROCK2B,HRAS,FGFR3,ITGA3B,ITGB1,CFL2,MYL12.1,FGF10 |
| Proteoglycans in cancer | WNT8A,ITGAV,PDCD4,AKT2,LUM,FAS,RPS6KB2,CAMK2G,TLR2,RPS6 |
| Tight junction | CLDNE,CLDN17,MYL9A,GNAI2B,CLDN19,VMHC,HRASA,PRKCE,CLDNB,MLLT4 |
| Rap signaling pathway | FGF21,PRKD3,KRIT1,LPAR5,LPAR3,FIGF,PIK3CA,Itgam&Itgb2,TEK,VASP |
Protein Function
MRAS has several biochemical functions, for example, GTP binding,GTP-dependent protein binding,GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MRAS itself. We selected most functions MRAS had, and list some proteins which have the same functions with MRAS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP-dependent protein binding | AP1G1,GCHFR,GCH1,RAB38,PPIAL4A,RASGRP4,RAB5B,ARFIP2,HPS6,AP3B1 |
| GTP binding | DRG2,SEPT4,GIMAP7,RAB10,EHD2B,ARHGAP5,RAB9A,SEPT12,AK3,ERAS |
| protein binding | RFX5,KCNN4,SEMA4A,VTI1B,NUP153,RNF24,IREB2,DLG3,SPDYE2,KLF3 |
| GTPase activity | CDC42,GNA15.4,DNM2,LRRK2,RALB,LGALS6,ARL1,RABL2B,RAB13,GNAO1 |
Interacting Protein
MRAS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRAS here. Most of them are supplied by our site. Hope this information will be useful for your research of MRAS.
MLLT4;TCEB1;Rassf5;PLXNB1
MRAS Related Signal Pathway
Resources
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References
- Kassan, M; Galan, M; et al. Interleukin-10 Released by CD4(+)CD25(+) Natural Regulatory T Cells Improves Microvascular Endothelial Function Through Inhibition of NADPH Oxidase Activity in Hypertensive Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 31:2534-U427(2011).
- Novelli, G; Morabito, V; et al. Management of Sepsis During MARS Treatment in Acute on Chronic Liver Failure. TRANSPLANTATION PROCEEDINGS 43:1085-1090(2011).
