MPP1
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Official Full Name
membrane protein, palmitoylated 1, 55kDa -
Overview
This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
MPP1;membrane protein, palmitoylated 1, 55kDa;DXS552E, membrane protein, palmitoylated 1 (55kD);55 kDa erythrocyte membrane protein;PEMP;palmitoylated 1;AAG 12;AAG12;Aging associated gene 12;DXS552;DXS552E;EM55_HUMAN;EMP 55;EMP55;Erythrocyte membrane protein p55;Membrane protein;Membrane protein palmitoylated 1 55kDa;Membrane protein palmitoylated 1;Migration related gene 1;MPP 1;MRG 1;MRG1;OTTHUMP00000026054;OTTHUMP00000196176;p55;Palmitoylated erythrocyte membrane protein;Palmitoylated membrane protein 1;aging-associated gene 12;migration-related gene 1
Recombinant Proteins
- Zebrafish
- Chicken
- Rhesus macaque
- Human
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
MPP1 involved in several pathways and played different roles in them. We selected most pathways MPP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MPP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MPP1 has several biochemical functions, for example, guanylate kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MPP1 itself. We selected most functions MPP1 had, and list some proteins which have the same functions with MPP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| guanylate kinase activity | DLG1L,DLG4,CARD11,GUK1B,GUK1A,DLG1,GUK1,DLG2,CASK,TJP2 |
| protein binding | RAD9,DUSP13,SDCBP,DMAP1,RPS28,GSTA4,GNA13,MTIF3,TH1L,MET |
Interacting Protein
MPP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MPP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MPP1.
KLHL12;DNPEP;GYPC;OPTN;SGSM2;TK1;GADD45A;ATP5C1;GSK3B;NR1H2;STK3;RPS6KA1;SMN1;ZAK
Resources
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References
- Alahmad, A; Preuss, KD; et al. Desmoplakin and KIF20B as target antigens in patients with paroxysmal nocturnal haemoglobinuria. BRITISH JOURNAL OF HAEMATOLOGY 151:273-280(2010).
- Berg, CP; Kannan, TR; et al. Mycoplasma antigens as a possible trigger for the induction of antimitochondrial antibodies in primary biliary cirrhosis. LIVER INTERNATIONAL 29:797-809(2009).
