MPLKIP
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Official Full Name
M-phase specific PLK1 interacting protein -
Overview
The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy. [provided by RefSeq, Nov 2009] -
Synonyms
MPLKIP;M-phase specific PLK1 interacting protein;ABHS;ORF20;C7orf11;M-phase-specific PLK1-interacting protein;Russell-Silver syndrome region;TTD non-photosensitive 1 protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MPLKIP-5218H | Recombinant Human MPLKIP Protein, GST-tagged | Wheat Germ | Human | GST |
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| MPLKIP-7987Z | Recombinant Zebrafish MPLKIP | Mammalian Cells | Zebrafish | His |
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| MPLKIP-7975HCL | Recombinant Human C7orf11 293 Cell Lysate | HEK293 | Human | Non |
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| MPLKIP-3849HF | Recombinant Full Length Human MPLKIP Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 179 amino acids |
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Involved Pathway
MPLKIP involved in several pathways and played different roles in them. We selected most pathways MPLKIP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MPLKIP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
MPLKIP has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MPLKIP itself. We selected most functions MPLKIP had, and list some proteins which have the same functions with MPLKIP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GAS6,CRB3,CTR9,POLR2J,EPO,OTUB2,TRP53,PPP1R13L,CENPK,SOSTDC1B |
Interacting Protein
MPLKIP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MPLKIP here. Most of them are supplied by our site. Hope this information will be useful for your research of MPLKIP.
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References
- Kang, YH; Park, CH; et al. Mammalian Polo-like Kinase 1-dependent Regulation of the PBIP1-CENP-Q Complex at Kinetochores. JOURNAL OF BIOLOGICAL CHEMISTRY 286:19744-19757(2011).
- Terasawa, M; Shinohara, A; et al. Canonical Non-Homologous End Joining in Mitosis Induces Genome Instability and Is Suppressed by M-phase-Specific Phosphorylation of XRCC4. PLOS GENETICS 10:-(2014).
