MMACHC
-
Official Full Name
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria -
Overview
The exact function of the protein encoded by this gene is not known, however, its C-terminal region shows similarity to TonB, a bacterial protein involved in energy transduction for cobalamin (vitamin B12) uptake. Hence, it is postulated that this protein may have a role in the binding and intracellular trafficking of cobalamin. Mutations in this gene are associated with methylmalonic aciduria and homocystinuria type cblC. -
Synonyms
MMACHC;methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria;methylmalonic aciduria and homocystinuria type C protein;cblC;DKFZP564I122;1810037K07Rik;BOS_3654;FLJ25671;Methylmalonic aciduria (cobalamin deficiency) cblC type with homocystinuria;Methylmalonic aciduria and homocystinuria type C protein homolog;MGC134307;OTTHUMP00000009243;RP11 291L19.3;RP23-177C18.3;RP11-291L19.3
Recombinant Proteins
- Rhesus macaque
- Chicken
- Human
- Zebrafish
- Mouse
- Mammalian Cells
- HEK293
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- His
- Myc&DDK
- Non
- His&Fc&Avi
- GST
Involved Pathway
MMACHC involved in several pathways and played different roles in them. We selected most pathways MMACHC participated on our site, such as Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMACHC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vitamin digestion and absorption | APOA1,GIF,FOLH1,TCN2,APOB,SLC19A2,RBP2,PNLIP,ABCC1,SLC46A1 |
Protein Function
MMACHC has several biochemical functions, for example, cobalamin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMACHC itself. We selected most functions MMACHC had, and list some proteins which have the same functions with MMACHC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TAOK3,C12orf40,SSU72,GRASP,AGGF1,SIX5,EFEMP2,IFI30,VGLL2,NOXA1 |
| cobalamin binding | CD320,LMBRD1,MUT,TCNL,GIF,CUBN,TCN2,TCN1 |
Interacting Protein
MMACHC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMACHC here. Most of them are supplied by our site. Hope this information will be useful for your research of MMACHC.
MTR
Resources
Related Services
Related Products
References
