MLLT11
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Official Full Name
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -
Overview
The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. -
Synonyms
MLLT11;myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila);translocated to, 11;protein AF1q;AF1Q;ALL1 fused gene from chromosome 1q;MLLT 11;Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog, Drosophila) translocated to 11;RP11 316M1.10;OTTHUMP00000033120;ALL1-fused gene from chromosome 1q;RP11-316M1.10
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His&T7
- His
- His&Fc&Avi
Involved Pathway
MLLT11 involved in several pathways and played different roles in them. We selected most pathways MLLT11 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MLLT11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MLLT11 has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by MLLT11 itself. We selected most functions MLLT11 had, and list some proteins which have the same functions with MLLT11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | FAM151A,PDCD10B,TMEM167,LIN54,C21orf56,GM7861,C1orf123,NUP210L,GAGE2A,TMEM235 |
Interacting Protein
MLLT11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLLT11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MLLT11.
HBZ;P;DNAJA4
Resources
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References
- Baird, JH; Minniti, CP; et al. Oscillatory haematopoiesis in adults with sickle cell disease treated with hydroxycarbamide. BRITISH JOURNAL OF HAEMATOLOGY 168:737-746(2015).
- Lohsen, S; Majumder, P; et al. Common distal elements orchestrate CIITA isoform-specific expression in multiple cell types. GENES AND IMMUNITY 15:543-555(2014).
