MICU1
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Official Full Name
mitochondrial calcium uptake 1 -
Overview
This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013] -
Synonyms
MICU1;mitochondrial calcium uptake 1;CALC;EFHA3;MPXPS;CBARA1;calcium uptake protein 1, mitochondrial;ara CALC;atopy-related autoantigen CALC;calcium-binding atopy-related autoantigen 1
Recombinant Proteins
- Rat
- Human
- Zebrafish
- Mouse
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
MICU1 involved in several pathways and played different roles in them. We selected most pathways MICU1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MICU1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MICU1 has several biochemical functions, for example, calcium ion binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MICU1 itself. We selected most functions MICU1 had, and list some proteins which have the same functions with MICU1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | CAPS,PCDHGB2,ICN2,CIB4,SYT17,PLA2G12B,PCDHA4,THBS4B,PCDH7,GUCA1A |
| protein heterodimerization activity | UGT1A4,CUL5,ANO9A,SNX6,LIMK1,TCF12,KCNK9,PPARD,CYBA,BMP6 |
| identical protein binding | IMPA1,ALDOA,KCNIP2,TPRGL,ZNF212,ATL1,IK,BCAT1,ERBB3,SERPINA1E |
| protein binding | TM4SF4,NEK3,CTDNEP1,KIRREL2,RNF180,SPATA13,KRAS,SCOC,ISYNA1,KCNG4 |
Interacting Protein
MICU1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MICU1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MICU1.
SQSTM1;MCU;BABAM1;ssrna_ag;SLX4
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References
- Matsuzaki, H; Fujimoto, T; et al. Tespa1 is a novel component of mitochondria-associated endoplasmic reticulum membranes and affects mitochondrial calcium flux. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 433:322-326(2013).
- Xiong, C; Li, JX; et al. The H-1-H-2 domain of the alpha(1) isoform of Na+-K+-ATPase is involved in ouabain toxicity in rat ventricular myocytes. TOXICOLOGY AND APPLIED PHARMACOLOGY 262:32-42(2012).
