MIB1
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Official Full Name
mindbomb E3 ubiquitin protein ligase 1 -
Overview
The MIB1 protein is an E3 ubiquitin-protein ligase that mediates ubiquitination of delta receptors, which act as ligands of Notch proteins. It positively regulates the delta-mediated Notch signaling by ubiquitinating the intracellular domain of delta, leading to endocytosis of delta receptors. It probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis. -
Synonyms
MIB1;mindbomb E3 ubiquitin protein ligase 1;mindbomb homolog 1 (Drosophila);E3 ubiquitin-protein ligase MIB1;DIP 1;KIAA1323;MIB;ZZANK2;ZZZ6;mindbomb homolog 1;mind bomb homolog 1;DAPK-interacting protein 1;ubiquitin ligase mind bomb;ubiquitin ligase protein MIB1;zinc finger ZZ type with ankyrin repeat domain protein 2;DIP-1;FLJ90676;MGC129659;MGC129660;DKFZp686I0769;DKFZp761M1710
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- Wheat Germ
- GST
- His
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
- His&T7
Involved Pathway
MIB1 involved in several pathways and played different roles in them. We selected most pathways MIB1 participated on our site, such as Activated NOTCH1 Transmits Signal to the Nucleus,Constitutive Signaling by NOTCH1 HD Domain Mutants,Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, which may be useful for your reference. Also, other proteins which involved in the same pathway with MIB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | CDK8,JAG2,HDAC5,HEY2,CCNC,ADAM10,JAG1,HDAC6,HEYL,HEY1 |
| Notch signaling pathway | HER9,JAG2B,LNX1,HDAC1,HDAC2,DTX3,DLL3,ADAM17A,MFNG,RBPJA |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | HEYL,HEY2,ADAM10,HDAC6,HEY1,JAG1,CDK8,CCNC,JAG2,HDAC5 |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | JAG1,JAG2,ADAM10 |
| Disease | KPNA4,KPNA3,PPIA,KPNA5,FGFR1OP,FKBP1A,DPF1,TNKS2,CHMP4B,OPN1LW |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | MDKB,MDKA,CNTN1,MDK |
| Activated NOTCH1 Transmits Signal to the Nucleus | CNTN1,JAG2,DLK1,JAG1,ADAM10,DNER,DTX2 |
| Diseases of signal transduction | DERL2,HEY2,CTBP1,HEYL,OPN1MW2,TNKS2,OS9,CCNC,CDK8,JAG1 |
Protein Function
MIB1 has several biochemical functions, for example, ligase activity,protein binding,ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MIB1 itself. We selected most functions MIB1 had, and list some proteins which have the same functions with MIB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | TRIM35-23,PML,PMPCB,KNG1,MARCH11,PDLIM5,ZDHHC2,ADAM15,GATA1,P2RX4 |
| protein binding | RIPPLY2,SEMA4D,LCA5,CCDC93,WDR4,ERGIC1,BIN1,MGST1,LGALS6,FAM98A |
| ubiquitin-protein transferase activity | PRKCQ,RNF220,BIRC5B,TRAF3,KLHL20,BRAP,XIAP,MARCH5L,DZIP3,FBXL6 |
| ligase activity | STUB1,MKRN1,RNF169,LIG4,LRSAM1,UBR1,TRIM33,PELI2,RNF111,PCXB |
Interacting Protein
MIB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MIB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MIB1.
Cep131;Azi2;TBK1;UBE2D1;UBE2D3;UBE2N;UBE2D2;UBE2U;UBE2W;UBE2D4;SNX5;Lrrcc1;Ankrd26;OFD1;PCNT;FGFR1OP;MYC
MIB1 Related Signal Pathway
Resources
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References
- Voros, A; Csorgo, E; et al. Different Methods of Pretreatment Ki-67 Labeling Index Evaluation in Core Biopsies of Breast Cancer Patients Treated with Neoadjuvant Chemotherapy and Their Relation to Response to Therapy. PATHOLOGY & ONCOLOGY RESEARCH 21:147-155(2015).
- Ekholm, M; Beglerbegovic, S; et al. Immunohistochemical assessment of Ki67 with antibodies SP6 and MIB1 in primary breast cancer: a comparison of prognostic value and reproducibility. HISTOPATHOLOGY 65:252-260(2014).
