MGST1
-
Official Full Name
microsomal glutathione S-transferase 1 -
Overview
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Four transcript variants of this gene encode one protein isoform. -
Synonyms
MGST1;microsomal glutathione S-transferase 1;GST12;MGST I;Glutathione S transferase 12;MGST 1;MGST;MGST1_HUMAN;Microsomal GST 1;Microsomal GST-1;Microsomal GST-I;glutathione S-transferase 12;MGST-I
Recombinant Proteins
- Human
- Mouse
- Chicken
- Cynomolgus
- Rat
- Sus scrofa (Pig)
- Mus musculus
- Bovine
- Mammalian Cells
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- HEK293
- His
- His&GST
- Non
- His&Fc&Avi
- GST
Involved Pathway
MGST1 involved in several pathways and played different roles in them. We selected most pathways MGST1 participated on our site, such as Glutathione metabolism,Metabolism of xenobiotics by cytochrome P,Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGST1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutathione metabolism | GGT1,GSS,GPX5,GSTK1,ODC1,RRM2B,GGT6,GGT5,GSTA,GSTA5 |
| Drug metabolism - cytochrome P | GSTT2,ALDH3A1,FMO3,GSTO1,MGST2,UGT1A6,FMO5,UGT1A2,MGST3,AOX4 |
| Chemical carcinogenesis | CYP2C55,UGT1A7,CYP2C50,CYP3A4,CYP3A25,CYP3A43,ALDH1A3,GSTM6,UGT1A3,GSTA1 |
| Metabolism of xenobiotics by cytochrome P | GSTM7,GSTA3,GSTM3,GSTP1,UGT1A6A,AKR7A5,UGT1AB,CYP2F2,ADH1,GSTA1 |
Protein Function
MGST1 has several biochemical functions, for example, glutathione binding,glutathione peroxidase activity,glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MGST1 itself. We selected most functions MGST1 had, and list some proteins which have the same functions with MGST1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | TRIM5,PAFAH1B1,GSTM4,TREX2,GZMA,ANO6,ZBTB16,BAK1,GPD1A,ADIPOQ |
| glutathione peroxidase activity | GPX1,GSTT1,LTC4S,GRX2,MGST3,GPX2,GPX6,GPX5,GPX7,GSTK1 |
| glutathione binding | GSS,GSTM1,GSTM2,LANCL1,GPX1,LTC4S,PTGES2,GSTM3,GSTM4,PTGESL |
| glutathione transferase activity | GSTM1,GSTA4,GSTA1,GSTA3,GSTA5,GSTO2,GSTP2,GSTAL,EEF1G,GSTP1 |
| protein binding | SCARB2,BAAT,RNF13,MMP20,C1QTNF1,CBX1,PVR,NT5C3B,C9orf24,DAZL |
Interacting Protein
MGST1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGST1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MGST1.
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References
- Weng, ZQ; Greenhaw, J; et al. Mechanisms for epigallocatechin gallate induced inhibition of drug metabolizing enzymes in rat liver microsomes. TOXICOLOGY LETTERS 214:328-338(2012).
- Boczek, T; Kozaczuk, A; et al. Adaptation of microsomal glutathione transferase 1 in PC12 cells with modified PMCA isoforms composition. INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS 47:265-271(2010).
