MGRN1
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Official Full Name
mahogunin, ring finger 1 -
Overview
Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro. -
Synonyms
MGRN1;mahogunin, ring finger 1;E3 ubiquitin-protein ligase MGRN1;KIAA0544;RNF156;Mahogunin ring finger 1;Mahogunin RING finger protein 1;MGRN 1;MGRN1_HUMAN;Probable E3 ubiquitin protein ligase MGRN1;RING finger protein 156;RNF 156;probable E3 ubiquitin-protein ligase MGRN1
Recombinant Proteins
- Human
- Rat
- Mouse
- Sf9 Cells
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
MGRN1 involved in several pathways and played different roles in them. We selected most pathways MGRN1 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGRN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | MDM2,UBE2E1,UBE2D2L,ANAPC5,TRIM37,KLHL9,HERC3,BIRC2,MID1,UBE3B |
Protein Function
MGRN1 has several biochemical functions, for example, ligase activity,protein binding,ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MGRN1 itself. We selected most functions MGRN1 had, and list some proteins which have the same functions with MGRN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | TRIM33,DTX1,UBE4B,CDC34B,TRIM4,MARCH1,TTLL11,SH3RF1,COP1,MSL2 |
| ubiquitin-protein transferase activity | TSPAN17,FBXO30A,RNF144AA,HUWE1,FBXO11,UBE3C,MIB1,AMFR,CDC23,RNF5 |
| zinc ion binding | ZCCHC16,Adamts19,RFPL2,LMO7,SNRPC,LHX1A,ZFP37,MME,PDZRN4,TRIM35-31 |
| ubiquitin protein ligase activity | HECTD3,RNF7,RABGEF1,CDC42,CBLC,UBE2G2,AMFR,UBR2,TMEM189,FBXO6 |
| protein binding | TPM1,ZNF511,RDBP,RGS3,LRRC25,ELF4,SIX1,THAP6,RAD9B,PSMA3 |
Interacting Protein
MGRN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGRN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MGRN1.
TSG101;GDU1;UBE2D1;UBE2E1;UBE2G2;UBE2D3;UBE2D2;UBE2I;GDU7;GDU5;GDU6;TRIM74;GDU4
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References
- Chhangani, D; Nukina, N; et al. Mahogunin ring finger 1 suppresses misfolded polyglutamine aggregation and cytotoxicity. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1842:1472-1484(2014).
- Srivastava, D; Chakrabarti, O; et al. Mahogunin-mediated alpha-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation. CELL DEATH & DISEASE 5:-(2014).
