MGAT1
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Official Full Name
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase -
Overview
There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. -
Synonyms
MGAT1;mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase;GLYT1, MGAT;alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase;GLCNAC TI;GNT 1;glcNAc-T I;N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosam
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Rat
- Rabbit
- Mus musculus
- Oryctolagus cuniculus (Rabbit)
- Mammalian Cells
- E.coli
- Wheat Germ
- E.Coli/Yeast
- HEK293
- In Vitro Cell Free System
- His
- Non
- His&GFP
- His&Fc&Avi
- N-His&C-Myc
- GST
Involved Pathway
MGAT1 involved in several pathways and played different roles in them. We selected most pathways MGAT1 participated on our site, such as N-Glycan biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | CMPK1,UGT1A2,COX15,PIGQ,CES1,ATP6V1E1B,UGP2B,GNS,HAAO,C1GALT1C1 |
| N-Glycan biosynthesis | MAN2A2,FUT8A,STT3B,MGAT5,ALG1,DOLK,ALG2,ALG14,ALG12,ZNF408 |
Protein Function
MGAT1 has several biochemical functions, for example, acetylglucosaminyltransferase activity,alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MGAT1 itself. We selected most functions MGAT1 had, and list some proteins which have the same functions with MGAT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acetylglucosaminyltransferase activity | B3GNT9-PS,A4GNT,GALNTL4,C3orf39,POMGNT2,MGAT1A,HEXA,GTDC2,HEXB,GALNT18A |
| metal ion binding | HBAE3,NUDT1,PVALB3,MUTYH,ZNF524,ZEB2,GART,ELAC2,CYP2Y3,TIMM8B |
Interacting Protein
MGAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MGAT1.
SMAD9;MAPK6;Anapc13;Mus81;Mad2l1
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References
- Sealover, NR; Davis, AM; et al. Engineering Chinese Hamster Ovary (CHO) cells for producing recombinant proteins with simple glycoforms by zinc-finger nuclease (ZFN)-mediated gene knockout of mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (Mgat1). JOURNAL OF BIOTECHNOLOGY 167:24-32(2013).
- Williams, SA; Stanley, P; et al. Complex N-glycans or core 1-derived O-glycans are not required for the expression of stage-specific antigens SSEA-1, SSEA-3, SSEA-4, or Le(Y) in the preimplantation mouse embryo. GLYCOCONJUGATE JOURNAL 26:335-347(2009).
