MFNG
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Official Full Name
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -
Overview
This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. -
Synonyms
MFNG;MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase;manic fringe (Drosophila) homolog , manic fringe homolog (Drosophila);beta-1,3-N-acetylglucosaminyltransferase manic fringe;O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase;OTTHUMP00000197828
Recombinant Proteins
- Zebrafish
- Mouse
- Human
- Rat
- Mus musculus
- Mammalian Cells
- HEK293
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- T7
- GST
- Avi
- Fc
Involved Pathway
MFNG involved in several pathways and played different roles in them. We selected most pathways MFNG participated on our site, such as Other types of O-glycan biosynthesis,Notch signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MFNG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Other types of O-glycan biosynthesis | B3GAT1,FUT9A,PLOD3,POFUT1,FUT4,ST6GAL1,ST3GAL3,CHST10,EOGT,ST6GAL2 |
| Notch signaling pathway | DLL4,ADAM17A,NCSTN,NOTCH4,HDAC1,NUMB,NOTCH3,DLL1,HER15.1,HER6 |
Protein Function
MFNG has several biochemical functions, for example, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MFNG itself. We selected most functions MFNG had, and list some proteins which have the same functions with MFNG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | PPP4C,ZNF502,EPX,HMGCLL1,PON3,ZNF571,MAP3K13,GALNT11,NUDT14,ITGA10 |
| O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity | RFNG,LFNG |
Interacting Protein
MFNG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MFNG here. Most of them are supplied by our site. Hope this information will be useful for your research of MFNG.
MFNG Related Signal Pathway
Resources
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References
- Azam, SS; Akhunzada, MJ; et al. Structure and dynamic studies of lunatic, manic and radical fringe. JOURNAL OF MOLECULAR LIQUIDS 188:186-195(2013).
- Gu, W; Xu, WG; et al. Fringe Controls Naive CD4(+)T Cells Differentiation through Modulating Notch Signaling in Asthmatic Rat Models. PLOS ONE 7:-(2012).
