MFN2
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Official Full Name
mitofusin 2 -
Overview
Mitofusin 2 (MFN2) is an important transmembrane GTPase required for mitochondrial fusion. MFN2 has a role in the regulation of vascular smooth muscle cell proliferation. The protein is highly expressed in heart and skeletal muscle and ubiquitously expres -
Synonyms
MFN2;mitofusin 2;mitofusin-2;CMT2A2;CPRP1;KIAA0214;MARF;hyperplasia suppressor;transmembrane GTPase MFN2;mitochondrial assembly regulatory factor;HSG;CMT2A
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- Mus musculus
- HEK293
- Mammalian Cells
- E.coli
- Wheat Germ
- DDK
- Myc
- His
- Non
- Avi
- Fc
- Flag
- GST
Involved Pathway
MFN2 involved in several pathways and played different roles in them. We selected most pathways MFN2 participated on our site, such as Factors involved in megakaryocyte development and platelet production,Hemostasis,Mitophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with MFN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitophagy | LC3,TOMM40,TOMM22,MAP1LC3B,MTERFD1,TOMM20,TOMM6,TOMM7,TOMM5,MFN1 |
| Hemostasis | SLC3A2B,HBD,KIF4,TREM1,F13A1B,CEACAM6,HBB-Y,KIF5B,VPS45,CEACAM1 |
| Factors involved in megakaryocyte development and platelet production | H3F3B.1,EHD1,GATA5,MYB,DOCK6,LRRC16A,MAFGA,HBB-BH1,AKAP1B,MFN1 |
| Pink/Parkin Mediated Mitophagy | MFN1,TOMM70A,TOMM20,MTERFD1,TOMM5,LC3,TOMM22,TOMM7,TOMM6,TOMM40 |
Protein Function
MFN2 has several biochemical functions, for example, GTP binding,GTPase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MFN2 itself. We selected most functions MFN2 had, and list some proteins which have the same functions with MFN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | RHOA,GNA11,GMPPAA,RALBB,ARL4D,EIF5B,GNAO1,RAB44,NUDT16,ARF6 |
| ubiquitin protein ligase binding | UBE2O,UBE2U,SMAD7,TRIOBP,HSPA1B,NEDD8,TNFRSF1B,ATP6V0C,PRKAR2B,MAGEC2 |
| GTPase activity | RAB39A,RAB7,RAB32A,RAB1B,RASEF,GNAZ,GSPT2,TUBE1,RAB34,RND1 |
| protein binding | TRPV6,STXBP3,SLC3A2,HFE,SMARCB1,PTPLAD1,ALKBH3,NAT9,RPS6KB1,FAIM |
Interacting Protein
MFN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MFN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MFN2.
LRRK2;VCP;TCHP;MARCH5;BAK1
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References
- Li, J; Ke, WB; et al. Tumour necrosis factor- alpha promotes liver ischaemia-reperfusion injury through the PGC-1 alpha/Mfn2 pathway. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 18:1863-1873(2014).
- Pinne, M; Matsunaga, J; et al. Leptospiral Outer Membrane Protein Microarray, a Novel Approach to Identification of Host Ligand-Binding Proteins. JOURNAL OF BACTERIOLOGY 194:6074-6087(2012).
