MED4
-
Official Full Name
mediator complex subunit 4 -
Overview
This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
MED4;mediator complex subunit 4;mediator of RNA polymerase II transcription, subunit 4 homolog (S. cerevisiae) , VDRIP, vitamin D receptor interacting protein;mediator of RNA polymerase II transcription subunit 4;DRIP36;HSPC126;TRAP36;Activator-recruited cofactor 36 kDa component;ARC36;FLJ10956;MED4_HUMAN;Mediator of RNA polymerase II transcription, subunit 4 homolog;OTTHUMP00000018390;OTTHUMP00000018391;OTTHUMP00000018392;RP11-90M2.2;TRAP/SMCC/PC2 subunit p36 subunit;VDRIP;Vitamin D3 receptor-interacting protein complex 36 kDa component
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
MED4 involved in several pathways and played different roles in them. We selected most pathways MED4 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone signaling pathway | PRKACG,ATP1A1,HDAC1,ITGAV,NCOR1,GSK3B,ATP1B1,KAT2B,BMP4,NRAS |
Protein Function
MED4 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity,ligand-dependent nuclear receptor transcription coactivator activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED4 itself. We selected most functions MED4 had, and list some proteins which have the same functions with MED4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | TNFRSF17,TNFRSF6B,MED14,LRP2,TLR3,APLNR,NLGN3B,NLGN2,EXTL3,NOTCH1 |
| ligand-dependent nuclear receptor transcription coactivator activity | ZMIZ2,HMGA1,PSMC3IP,HELZ2,SRA1,TADA3,SFR1,PPARG,PKN1,LRP2BP |
| transcription cofactor activity | MAP3K7,MED13,LDB1A,MED1,NMI,TAF13,BTG1,MED17,PHF21B,MXD1 |
| vitamin D receptor binding | TAF7,THRAP3,RXRA,MED24,MED30,MED16,TAF11,RUNX2B,MED17,SNW1 |
| thyroid hormone receptor binding | TAF11,PRMT2,NR0B2,GAS2L1,TAF7,HMGN3,NUP62,MED12,MED13,FUS |
| protein binding | POLDIP2,CD19,BICD1,GREM1,LDLR,APP,PTEN,MIEN1,GATA1A,INTS12 |
| RNA polymerase II transcription cofactor activity | MED26,MED13L,MED9,RBM14,MED13B,MED13A,PPARGC1A,PPRC1,MED31,MED11 |
Interacting Protein
MED4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED4.
MED10;MED9;MED19;MED26
Resources
Related Services
Related Products
References
- Gomez-Garcia, MR; Serrano, A; et al. Expression studies of two paralogous ppa genes encoding distinct Family I pyrophosphatases in marine unicellular cyanobacteria reveal inactivation of the typical cyanobacterial gene. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 295:890-897(2002).
- Garczarek, L; van der Staay, GWM; et al. Isolation and characterization of photosystem I from two strains of the marine oxychlorobacterium Prochlorococcus. PHOTOSYNTHESIS RESEARCH 56:131-141(1998).
- Partensky, F; LaRoche, J; et al. The divinyl-chlorophyll a/b-protein complexes of two strains of the oxyphototrophic marine prokaryote Prochlorococcus - Characterization and response to changes in growth irradiance. PHOTOSYNTHESIS RESEARCH 51:209-222(1997).
