MED27

  • Official Full Name

    mediator complex subunit 27

  • Overview

    The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.

  • Synonyms

    MED27;mediator complex subunit 27;cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa , CRSP8;mediator of RNA polymerase II transcription subunit 27;CRSP34;TRAP37;CRSP complex subunit 8;p37 TRAP/SMCC/PC2 subunit;transcriptional

Recombinant Proteins

  • Zebrafish
  • Human
  • Rhesus macaque
  • Chicken
  • Mouse
  • Mammalian Cells
  • E.coli
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
MED27-10929Z Recombinant Zebrafish MED27 Mammalian Cells Zebrafish His
MED27-157H Recombinant Human MED27, His-tagged E.coli Human His 1-311aa
MED27-1909H Recombinant Human MED27 Protein, GST-tagged Wheat Germ Human GST
MED27-2723R Recombinant Rhesus monkey MED27 Protein, His-tagged Mammalian Cells Rhesus macaque His
MED27-4755C Recombinant Chicken MED27 Mammalian Cells Chicken His
MED27-9699M Recombinant Mouse MED27 Protein Mammalian Cells Mouse His
MED27-4385HCL Recombinant Human MED27 293 Cell Lysate HEK293 Human Non
MED27-2109HF Recombinant Full Length Human MED27 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 70 amino acids
MED27-2543R Recombinant Rhesus Macaque MED27 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
MED27-2543R-B Recombinant Rhesus Macaque MED27 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
MED27-5455M Recombinant Mouse MED27 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
MED27-5455M-B Recombinant Mouse MED27 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    MED27 involved in several pathways and played different roles in them. We selected most pathways MED27 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED27 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid hormone signaling pathway MED1,ATP1B2,PRKACB,RAF1,ATP1B3,PFKFB2,ATP1A1,PRKCG,CCND1,MED13L

    Protein Function

    MED27 has several biochemical functions, for example, protein binding,transcription coactivator activity,ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED27 itself. We selected most functions MED27 had, and list some proteins which have the same functions with MED27. You can find most of the proteins on our site.

    Function Related Protein
    ubiquitin protein ligase activity MARCH1,UBR5,ITCH,FANCL,RNF34,HUWE1,MED24,UBE2V2,UBE2G1,TOPORS
    protein binding ZNF3,SMUG1,XBP1,CTRC,XK,FAM195A,TRIM27,ZNF2,HIST2H3C2,TECPR1
    transcription coactivator activity SAP130,PMF1,USP16,TAF7L,ECD,TAF1,MYSM1,TFDP1,GABPA,MAML1

    Interacting Protein

    MED27 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED27 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED27.

    MED10;MED19;MED22;Med30;CDK19;MED26;CDK8

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