MED26

  • Official Full Name

    mediator complex subunit 26

  • Overview

    The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.

  • Synonyms

    MED26;mediator complex subunit 26;cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa , CRSP7;mediator of RNA polymerase II transcription subunit 26;CRSP70;ARC70;CRSP complex subunit 7;transcriptional coactivator CRSP70;activato
Cat.# Product name Source (Host) Species Tag Protein Length Price
MED26-1908H Recombinant Human MED26 Protein, GST-tagged Wheat Germ Human GST
MED26-9698M Recombinant Mouse MED26 Protein Mammalian Cells Mouse His
MED26-406HCL Recombinant Human MED26 cell lysate Human Non
MED26-5454M Recombinant Mouse MED26 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
MED26-5454M-B Recombinant Mouse MED26 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    MED26 involved in several pathways and played different roles in them. We selected most pathways MED26 participated on our site, such as Developmental Biology,Fatty acid, triacylglycerol, and ketone body metabolism,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED26 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Generic Transcription Pathway ZNF596,YAP1,COX8A,CTGF,CCNC,ZNF729,NR4A2A,ZNF606,ZNF726,CDK8
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) MED9,MED20,MED21,GLIPR1,ANKRD1,PLIN2,MED7,G0S2,MED25,MED31
    PPARA activates gene expression CTGF,MED20,MTF1,MED18,MED31,MED29,MED19,GLIPR1,MED22,MED8
    Developmental Biology COL9A1A,RGMB,EFNB3,SPRED2,SPTBN1,GDF1,SCN3A,SPTBN2,LGI4,EPHB3A
    Fatty acid, triacylglycerol, and ketone body metabolism ACOT9,ACSF2,ELOVL1A,ACOT9.2,MED6,MED15,SLC25A1,ACOT13,HELZ2,ACOT12
    Metabolism TCN1,ALOX5B.2,ESRRA,ADSL,HS3ST4,FABP11A,AHCY,PDK4,COX10,ETFB
    Metabolism of lipids and lipoproteins DPEP1,AWAT2,CERS3B,MED16,CPTP,CLPS,NFYBB,GC,SREBF2,APOA4B.2
    Gene Expression RARG,ZKSCAN4,NR2C1,TSEN34,TNPO1,ZNF484,ZNF468,MTF2,AGO3B,ZNF143A

    Protein Function

    MED26 has several biochemical functions, for example, DNA binding,RNA polymerase II transcription cofactor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED26 itself. We selected most functions MED26 had, and list some proteins which have the same functions with MED26. You can find most of the proteins on our site.

    Function Related Protein
    transcription coactivator activity SMARCC2,MED20,HINFP,PRDM16,SRA1,NRIP1,NR1I3,E4F1,GRIP1,RBPMS
    RNA polymerase II transcription cofactor activity MED31,MED19,NKX2-5,PPARGC1B,MED10,TDG,MED30,RBM14,MED9,MDT-19
    protein binding HIST1H2AG,TPM4,ZNF473,MALL,PREP,HPGDS,PNKD,TEAD4,SSU72,MDM4
    DNA binding H1M,ZNF621,RFX2,PPARDB,PPP1R10,GM14477,ZNF71,SERPINA3,NUCB1,ZSCAN1

    Interacting Protein

    MED26 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED26 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED26.

    MED10;MED7;CDK19

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