MED23

  • Official Full Name

    mediator complex subunit 23

  • Overview

    The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

  • Synonyms

    MED23;mediator complex subunit 23;cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa , CRSP3;mediator of RNA polymerase II transcription subunit 23;CRSP130;DRIP130;Sur2;130 kDa transcriptional co activator;133 kDa transcriptional co activator;Activator recruited cofactor 130 kDa component;ARC 130;ARC130;Cofactor required for Sp1 transcriptional activation subunit 3 130kDa;Cofactor required for Sp1 transcriptional activation subunit 3 130kDa mediator;Cofactor required for Sp1 transcriptional activation subunit 3;CRSP 130;CRSP 130 kD subunit;CRSP 133;CRSP 3;CRSP complex subunit 3;CRSP133;CRSP3;CRSP3 protein;DKFZp434H0117;DRIP 130;KIAA1216;MED 23;SUR 2;Transcriptional co activator CRSP 130;Transcriptional co activator CRSP130;Vitamin D3 receptor interacting protein;Vitamin D3 receptor interacting protein complex 130 kDa component;130 kDa transcriptional co-activator;133 kDa transcriptional co-activator;activator-recruited cofactor 130 kDa component;MRT18;SUR-2

Recombinant Proteins

  • Human
  • Zebrafish
  • Rhesus macaque
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • GST
  • His
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
MED23-809H Recombinant Human MED23, GST-tagged E.coli Human GST 1014-1359aa
MED23-2697H Recombinant Human MED23 protein, His-tagged E.coli Human His 745 - 1059 aa
MED23-3121H Recombinant Human MED23 protein, His-tagged E.coli Human His 1-328 aa
MED23-1189Z Recombinant Zebrafish MED23 Mammalian Cells Zebrafish His
MED23-1906H Recombinant Human MED23 Protein, GST-tagged Wheat Germ Human GST
MED23-2722R Recombinant Rhesus monkey MED23 Protein, His-tagged Mammalian Cells Rhesus macaque His
MED23-2542R Recombinant Rhesus Macaque MED23 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
MED23-2542R-B Recombinant Rhesus Macaque MED23 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    MED23 involved in several pathways and played different roles in them. We selected most pathways MED23 participated on our site, such as Developmental Biology,Fatty acid, triacylglycerol, and ketone body metabolism,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED23 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism CYP26A1,BHMT2,B3GNT3,CYP8B2,B4GALT7,NFYAL,CYP2C18,MTF1,ACOT9.1,TMEM195
    Developmental Biology EFNA1A,MED6,GDNF,EFNB2,COL9A1A,DUSP9,EFNA1B,DPYSL5B,ADAM22,MYOD1
    Gene Expression ZNF624,JUNB,ZNF773,ZNF114,MTF2,ZNF23,TRDMT1,BRF2,SNAPC4,ZNF443
    Fatty acid, triacylglycerol, and ketone body metabolism ELOVL1A,SLC25A1,CDK8,ACOT6,ACOT11B,MED20,ACOT8,STIL,ACOT2,MED26
    PPARA activates gene expression MED31,ANKRD1,GRHL1,MED25,MTF1,MED20,MED15,MED22,CDK19,MED9
    Metabolism of lipids and lipoproteins PEMT,GLIPR1,FAM213B,ARSD,ACOT11B,ARV1,FAAH2A,ACOT9.2,SLC25A1A,CYP2AD2
    Generic Transcription Pathway NR2F6B,ZNF324,ZNF43,ZNF567,ZNF19,NR2C2AP,ZNF317,COX11,ZNF738,SKIA
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) MED6,MED29,PLIN2,GLIPR1,MED16,MED7,ANKRD1,MED9,MED19,MED25

    Protein Function

    MED23 has several biochemical functions, for example, protein binding,transcription coactivator activity,ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED23 itself. We selected most functions MED23 had, and list some proteins which have the same functions with MED23. You can find most of the proteins on our site.

    Function Related Protein
    ubiquitin protein ligase activity MSL2B,CBLC,CCNB1IP1,STUB1,SMURF2,RNF181,RNF41,TRIM72,CDK8,PJA1
    protein binding GEMIN8,BTC,FBXO28,SPON1,BMPR2,AMBP,PLAA,COG8,MOBP,AMMECR1
    transcription coactivator activity BRCA1,ZEB1,PSMC3,TRIM24,YAP1,SUPT3H,PRDM16,BRDT,MYOCD,DDX5

    Interacting Protein

    MED23 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED23 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED23.

    MED10;CDK19;MED19;MED26;CDK8;MED14;MED25;MED16;rluC;pyrG

    Resources

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