MED19
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Official Full Name
mediator complex subunit 19 -
Overview
MED19 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008] -
Synonyms
MED19;mediator complex subunit 19;LCMR1;DT2P1G7;mediator of RNA polymerase II transcription subunit 19;lung cancer metastasis-related protein 1;mediator of RNA polymerase II transcription, subunit 19 homolog
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- GST
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MED19-362H | Recombinant Human MED19 Protein, His-tagged | E.coli | Human | His |
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| MED19-9691M | Recombinant Mouse MED19 Protein | Mammalian Cells | Mouse | His |
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| MED19-4390HCL | Recombinant Human MED19 293 Cell Lysate | HEK293 | Human | Non |
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| MED19-4474H | Recombinant Human MED19 Protein, GST-tagged | Wheat Germ | Human | GST |
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| MED19-5449M | Recombinant Mouse MED19 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| MED19-5449M-B | Recombinant Mouse MED19 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| MED19-6213HF | Recombinant Full Length Human MED19 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 194 amino acids |
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Involved Pathway
MED19 involved in several pathways and played different roles in them. We selected most pathways MED19 participated on our site, such as Developmental Biology,Fatty acid, triacylglycerol, and ketone body metabolism,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional regulation of white adipocyte differentiation | MED22,EBF1,MED21,NR2F2,MED9,EGR2,MED18,MED29,CDK19 |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | MED25,MTF1,MED6,MED15,MED31,MED29,MED26,MED7,MED21,MED10 |
| Fatty acid, triacylglycerol, and ketone body metabolism | ACOT7,CCNC,THEM5,MED26,MED25,ACOT2,ACOT11B,ACSF3,GRHL1,ACOT10 |
| PPARA activates gene expression | MED9,MED16,MTF1,ANKRD1,MED8,MED6,PLIN2,MED23,MED15,MED7 |
| Metabolism of lipids and lipoproteins | ARSI,MTP,PLD6,LMF2,ACOT9.1,ALOX5AP,NEU3,CDIPT,PITPNB,DECR1 |
| Developmental Biology | WDR83,ARPC1A,SEMA4D,EFNB1,COL4A4,PTPRA,SCN2A,PSPN,SPRED3,TCF12 |
| Metabolism | Sult2a6,AQP1A.2,MED23,MAPK1IP1L,CYGB1,ACSF2,DGUOK,NDUFAF7,AS3MT,DCK |
Protein Function
MED19 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED19 itself. We selected most functions MED19 had, and list some proteins which have the same functions with MED19. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription cofactor activity | MED24,MED13,FOXH1,MED8,PPARGC1B,MED13A,MED4,MED7,MED19B,MED13B |
| protein binding | GREM1,TOX4,MATK,XIRP2,COMMD3,VLDLR,Arid4b,ZFP488,ARID1A,DPCD |
Interacting Protein
MED19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED19 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED19.
MED10;MED29
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References
- Wu, YM; Chang, JW; et al. Regulation of mammalian transcription by Gdown1 through a novel steric crosstalk revealed by cryo-EM. EMBO JOURNAL 31:3575-3587(2012).
