MCM5
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Official Full Name
minichromosome maintenance complex component 5 -
Overview
The MCM5 protein (minichromosome maintenance protein 5) is a nuclear 82 kD DNA-dependent ATPase. The MCM5 protein is a component of the DNA pre-replication complex that acts to allow DNA to undergo single round of replication per cell cycle. MCM5 is upreg -
Synonyms
MCM5;minichromosome maintenance complex component 5;CDC46, MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) , minichromosome maintenance deficient (S. cerevisiae) 5 (cell division cycle 46);DNA replication licensing
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- His
- His&GST
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MCM5-3254H | Recombinant Human MCM5 protein, His-tagged | E.coli | Human | His | 388-735 aa | |
| MCM5-009H | Recombinant Human MCM5 Protein, GST and His-tagged | E.coli | Human | His&GST | Full L. |
|
| MCM5-1390C | Recombinant Chicken MCM5 | Mammalian Cells | Chicken | His |
|
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| MCM5-28041TH | Recombinant Human MCM5, His-tagged | E.coli | Human | His | 217-734 a.a. |
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| MCM5-9604Z | Recombinant Zebrafish MCM5 | Mammalian Cells | Zebrafish | His |
|
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| MCM5-4417HCL | Recombinant Human MCM5 293 Cell Lysate | HEK293 | Human | Non |
|
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| MCM5-4520H | Recombinant Human MCM5 Protein (Val331-Ile537), N-His tagged | E.coli | Human | His | Val331-Ile537 |
|
Involved Pathway
MCM5 involved in several pathways and played different roles in them. We selected most pathways MCM5 participated on our site, such as DNA replication,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCM5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | UBE2V2,CDKN2C,YWHAQ,KIF2C,CEP290,THRSP,BRCC3,MCM6,CLSPN,MCM3L |
| DNA Replication | POLA2,PRIM2,RFC5,DBF4,MCM4,RFC1,RPA3,MCM2,RNASEH2B,MCM6L |
Protein Function
MCM5 has several biochemical functions, for example, ATP binding,DNA helicase activity,DNA replication origin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MCM5 itself. We selected most functions MCM5 had, and list some proteins which have the same functions with MCM5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SLC48A1,UBE2L6,KIF20B,ZFAND2B,SLC3A1,PEX11B,DNAJC19,FCN1,SYK,ALKBH8 |
| chromatin binding | SKIL,PAF1,SMAD6,SMC1AL,ATF2,HMGB2B,UBTFL,CENPA,HCFC1,NKX6-1 |
| ATP binding | GRK7A,AARS2,P2RX3A,NLRP14,ABCA9,DDR2,BCKDK,CHKB,ATP11C,WRNIP1 |
| DNA replication origin binding | HSPD1,MCM2,ORC4L,ORC2L,CDC45,MCM10,ORC3L,ORC4 |
| DNA helicase activity | ATRX,WRN,RUVBL2,INO80,CHD8,MCM3L,FBXO18,IGHMBP2,MCM2,SUPV3L1 |
Interacting Protein
MCM5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCM5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCM5.
MCMBP;MCM2;MCM3
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References
- Pentheroudakis, G; Kotoula, V; et al. A study of gene expression markers for predictive significance for bevacizumab benefit in patients with metastatic colon cancer: a translational research study of the Hellenic Cooperative Oncology Group (HeCOG). BMC CANCER 14:-(2014).
- Carlage, T; Kshirsagar, R; et al. Analysis of dynamic changes in the proteome of a Bcl-XL overexpressing Chinese hamster ovary cell culture during exponential and stationary phases. BIOTECHNOLOGY PROGRESS 28:814-823(2012).
