MCM4
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Official Full Name
minichromosome maintenance complex component 4 -
Overview
The MCM4 protein (minichromosome maintenance protein 4) is a nuclear 100 kD DNA-dependent ATPase. The MCM4 protein is a component of the DNA pre-replication complex that acts to allow DNA to undergo single round of replication per cell cycle. MCM4 togethe -
Synonyms
MCM4;minichromosome maintenance complex component 4;CDC21, MCM4 minichromosome maintenance deficient 4 (S. cerevisiae);DNA replication licensing factor MCM4;CDC54;hCdc21;MGC33310;P1 Cdc21;CDC21 homolog;minichromosome maintenance deficient 4;hom
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
MCM4 involved in several pathways and played different roles in them. We selected most pathways MCM4 participated on our site, such as DNA replication,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCM4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | MPEG1.1,NCAPG,LMNB1,SKA2,NDEL1B,CCNB3,ORC5,CDK2,DKC1,CCNB1 |
| DNA Replication | MCM7,MCM3,PCNA,SSBP1,RPA3,FEN1,RNASEH2C,RPA1,GMNN,PRIM2 |
Protein Function
MCM4 has several biochemical functions, for example, ATP binding,contributes_to ATP-dependent DNA helicase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MCM4 itself. We selected most functions MCM4 had, and list some proteins which have the same functions with MCM4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| single-stranded DNA binding | NABP2,RTF1,RBMS1,OBFC2B,TSNAX,RAD23A,SSBP4,SUB1,PURB,NEIL3 |
| ATP binding | FLT1,MYH8,PKZ,PRKCBB,UBE2D2,HUNK,ACSF2,GUCY2C,ORC4,PSMC4 |
| contributes_to ATP-dependent DNA helicase activity | MCM6,RAD50,MCM7,MRE11A,NBN |
| protein binding | RFX6,ICA1,GRIN2C,MPP7,EPHA3,SILV,FAM92A,PSMC5,ZNF26,MAD1L1 |
Interacting Protein
MCM4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCM4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCM4.
MCM7;MCMBP
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References
- Gan, N; Du, Y; et al. Increase of Mcm3 and Mcm4 expression in cervical squamous cell carcinomas. EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY 31:291-294(2010).
- Gambichler, T; Shtern, M; et al. Minichromosome maintenance proteins are useful adjuncts to differentiate between benign and malignant melanocytic skin lesions. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 60:808-813(2009).
