MCM3AP
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Official Full Name
minichromosome maintenance complex component 3 associated protein -
Overview
GANP (germinal center-associated nuclear protein) is up-regulated selectively in germinal centers and carries an MCM-binding domain in the carboxyl-terminal side. It was found that a region (from 414 to 550 aa) in GANP molecule that is slightly similar to the known DNA-primase component p49. The recombinant GANP fragment covering this region synthesizes RNA primers for extension by DNA polymerase I with single-stranded DNA templates in vitro. GANP DNA-primase activity is controlled by phosphorylation at Ser(502) that is induced by CD40-mediated signaling in vitro and in the germinal center B cells stimulated with antigen in vivo. Overexpression of ganp cDNA in Daudi B cells caused the increased DNA synthesis more than the levels of the mock-transfectants. These evidences suggested that the novel DNA-primase GANP is involved in regulation of cell proliferation of antigen-driven B cells in germinal centers. -
Synonyms
MCM3AP;minichromosome maintenance complex component 3 associated protein;MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein , minichromosome maintenance deficient (S. cerevisiae) 3 associated protein;80 kDa MCM3-associated protein;GANP;KIAA0572;Map80;MCM3 import protein;germinal center-associated nuclear protein;minichromosome maintenance deficient 3-associated protein;MCM3 minichromosome maintenance deficient 3 associated protein;FLJ44336;FLJ45306
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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| MCM3AP-4372H | Recombinant Human minichromosome maintenance complex component 3 associated protein, GST-Tagged | Human | Human | GST |
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| MCM3AP-9636M | Recombinant Mouse MCM3AP Protein | Mammalian Cells | Mouse | His |
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| MCM3AP-2430H | Recombinant Human MCM3AP Protein, His-tagged | E.coli | Human | His | Phe33-Arg340 |
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| MCM3AP-5412M | Recombinant Mouse MCM3AP Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| MCM3AP-5412M-B | Recombinant Mouse MCM3AP Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
MCM3AP involved in several pathways and played different roles in them. We selected most pathways MCM3AP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MCM3AP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
MCM3AP has several biochemical functions, for example, DNA binding,transferase activity, transferring acyl groups. Some of the functions are cooperated with other proteins, some of the functions could acted by MCM3AP itself. We selected most functions MCM3AP had, and list some proteins which have the same functions with MCM3AP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | UPF1,SP110,SAFB2,NR1I3,SMAD3B,ZBTB8B,BHLHE22,GTF2F2,PPARAA,NUCB1 |
| transferase activity, transferring acyl groups | ZDHHC16A,LIPT2,AANAT,TGM3,ZDHHC21,LPGAT1,CML2,NAT14,NAT15,NMT1B |
Interacting Protein
MCM3AP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCM3AP here. Most of them are supplied by our site. Hope this information will be useful for your research of MCM3AP.
SMAD9;CLSTN1;APC;CDC25A;CDC42;POLR2G;RAC1;SMAD3;EP300;CRMP1;TSC22D1;prlC;sdhA;CDC73;q7cgu5_yerpe;purR;hmwC;q81kk8_bacan;q81ye8_bacan;FAM118B
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References
- Horpaopan, S; Spier, I; et al. Genome-wide CNV analysis in 221 unrelated patients and targeted high-throughput sequencing reveal novel causative candidate genes for colorectal adenomatous polyposis. INTERNATIONAL JOURNAL OF CANCER 136:E578-E589(2015).
- Schuurs-Hoeijmakers, JHM; Vulto-van Silfhout, AT; et al. Identification of pathogenic gene variants in small families with intellectually disabled siblings by exome sequencing. JOURNAL OF MEDICAL GENETICS 50:802-811(2013).
