MCHR1
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Official Full Name
melanin-concentrating hormone receptor 1 -
Overview
The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. -
Synonyms
MCHR1;melanin-concentrating hormone receptor 1;G protein coupled receptor 24 , GPR24;MCH1R;SLC1;SLC-1;MCH-1R;MCH receptor 1;G protein-coupled receptor 24;somatostatin receptor-like protein;GPR24;MGC32129
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mus musculus
- Pan troglodytes
- Macaca mulatta
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
MCHR1 involved in several pathways and played different roles in them. We selected most pathways MCHR1 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCHR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | HRH2,CHRNA3,PTGER1A,MTNR1B,HTR6,APLNRB,P2RX3A,TAAR10C,ADORA2AA,TAAR9 |
Protein Function
MCHR1 has several biochemical functions, for example, G-protein coupled receptor activity,melanin-concentrating hormone receptor activity,neuropeptide receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MCHR1 itself. We selected most functions MCHR1 had, and list some proteins which have the same functions with MCHR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | SNX17,NUDT7,NPPA,PVRL3B,HNF4A,EPB49,SMAGP,PEX14,APOF,F7 |
| neuropeptide receptor activity | NPFFR1L2,KISS1RB,PRLHR,SORCS3,HCRTR2,NPSR1,KISS1R,NPBWR2,NPBWR1,NPFFR2 |
| G-protein coupled receptor activity | OPRD1B,NMUR1,OLFCG4,TAAR12I,TAS1R2.2,GPR125,UTS2R,OLFR480,CALCRLA,DRD4-RS |
Interacting Protein
MCHR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCHR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCHR1.
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References
- Philippe, C; Haeusler, D; et al. Comparative autoradiographic in vitro investigation of melanin concentrating hormone receptor 1 ligands in the central nervous system. EUROPEAN JOURNAL OF PHARMACOLOGY 735:177-183(2014).
- Kroon, MW; Kemp, EH; et al. Melanocyte antigen-specific antibodies cannot be used as markers for recent disease activity in patients with vitiligo. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 27:1172-1175(2013).
